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31 January 2019 : Review article  

Myosin Heavy Chain 9: Oncogene or Tumor Suppressor Gene?

Yunmei Wang1BCDEF, Shuguang Liu2BCDEF, Yanjun Zhang1AG*, Jin Yang3AG

DOI: 10.12659/MSM.912320

Med Sci Monit 2019; 25:888-892

Abstract

MYH9 was first discovered due to thrombocytopenia caused by MYH9 mutation-related abnormalities. In recent years, researchers have increasingly found that MYH9 plays an important role in cancer as a cytokine involved in cytoskeletal reorganization, cellular pseudopodia formation, and migration. MYH9 is closely related to the progress and poor prognosis of most solid tumors, and it is now accepted that MYH9 is a suppressor gene and plays an important role on the re-Rho pathway. Recent research has been limited to the study of tissues. However, it would be more direct and informative to be able to use hematology to assess tumor prognosis and changes in MYH9 levels and NMMHC-IIA. This article summarizes recent research on MYH9 and provides a reference for future clinical research.

Keywords: Adenomatous Polyposis Coli, Purpura, Thrombocytopenic, Idiopathic, Blood Platelets, Genes, Tumor Suppressor, Molecular Motor Proteins, Mutation, Myosin Heavy Chains, Oncogenes, Thrombocytopenia

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750