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05 November 2019 : Meta-Analysis  

Evidence from 40 Studies that 2 Common Single-Nucleotide Polymorphisms (SNPs) of RNASEL Gene Affect Prostate Cancer Susceptibility: A Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA)-Compliant Meta-Analysis

Jun Xia123CDEF, Rulin Sun124ABG*

DOI: 10.12659/MSM.917715

Med Sci Monit 2019; 25:8315-8325


BACKGROUND: Numerous studies have evaluated the relationship between RNASEL gene polymorphisms (rs486907 G>A and rs627928 T>G) and the risk of cancer. However, many of the results have been controversial. To explore the role of RNASEL gene polymorphisms in prostate cancer, we carried out the present meta-analysis.

MATERIAL AND METHODS: The qualified articles were collected from PubMed, Web of Science, Scopus, CNKI, and WanFang databases to August 2018. A total 23 articles with 40 studies were incorporated into our analysis.

RESULTS: Our data show that rs486907 was not associated with the risk of prostate cancer in any populations. Nevertheless, rs627928 was reported to promote the development of prostate cancer (T vs. G: OR=1.08, 95% CI=1.01–1.15; TT+TG vs. GG: OR=1.14, 95% CI=1.03–1.25) in allele and recessive models in overall populations. Stratified analyses showed that similar results were obtained in white populations.

CONCLUSIONS: We report the effect of rs627928 on the development of prostate cancer and confirm that rs486907 is not involved in the risk of prostate cancer in the current meta-analysis. However, research in larger populations is needed to validate our conclusions.

Keywords: Anus Neoplasms, Polymorphism, Single-Stranded Conformational, Ribonuclease, Pancreatic, Alleles, Asians, Case-Control Studies, Endoribonucleases, Gene Frequency, Genetic Predisposition to Disease, Odds Ratio, Polymorphism, Single Nucleotide, Prostatic Neoplasms, Risk Factors

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01 September 2023 : Editorial  

Editorial: A Rapid Global Increase in COVID-19 is Due to the Emergence of the EG.5 (Eris) Subvariant of Omicron SARS-CoV-2

Dinah V. Parums
Science Editor, Medical Science Monitor, International Scientific Information, Inc., Melville, NY, USA

DOI: 10.12659/MSM.942244

Med Sci Monit 2023; 29:e942244


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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750