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: Clinical Research  

[In Press] Renal Manifestations in Inflammatory Bowel Disease: A Cohort Study During the Biologic Era

Mevlut Tamer Dincer ORCID logo1ABCDEF, Zeynep Toker Dincer2BCE, Oguz Kagan Bakkaloglu3CEF, Serkan Feyyaz Yalin4BE, Sinan Trabulus1ADE, Aykut Ferhat Celik3AE, Nurhan Seyahi1CDE, Mehmet Riza Altiparmak1ACDE

Med Sci Monit In Press; DOI:   :: ID: 936497

Available online: , In Press, Corrected Proof

Publication in the "In-Press" formula aims at speeding up the public availability of the pending manuscript while waiting for the final publication. The assigned DOI number is active and citable. The availability of the article in the Medline, PubMed and PMC databases as well as Web of Science will be obtained after the final publication according to the journal schedule


Renal involvement can complicate the course of inflammatory bowel disease (IBD). In this study, we aimed to analyze the extent of renal manifestations in patients with IBD (Crohn disease or ulcerative colitis) during the biologic era.
Patients diagnosed with and followed up for IBD for a period covering 16 years were retrospectively analyzed. Patients who received IBD diagnosis with clinical, endoscopic, and histopathological findings and were older than 18 years were enrolled in the study. Demographic, clinical, laboratory, and treatment data were retrieved from the patients’ medical records.
Of the 1874 patients analyzed, the diagnosis was ulcerative colitis in 1055 patients and Crohn disease in the remaining 819. Renal manifestations were found in 105 patients (5.6%), 55 (6.7%) of whom were diagnosed with Crohn disease and 50 (4.7%) with ulcerative colitis. Renal calculi was the most common renal manifestation for both Crohn disease and ulcerative colitis. Renal manifestations were related to disease activity and surgical resection history in patients with Crohn disease, whereas no such relationship was found in patients with ulcerative colitis.
Renal manifestations may be seen in up to 6% of patients with IBD, and patients with Crohn disease seems to have more risk than do patients with ulcerative colitis. Nephrolithiasis is the most common form of renal involvement in IBD and is closely associated with disease activity. This relationship between IBD and renal manifestations should be considered, especially when there are subtle renal symptoms.

Keywords: Colitis, Ulcerative; Crohn Disease; Inflammatory Bowel Diseases; Nephrolithiasis


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Med Sci Monit 2022; 28:e937371

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Renal Manifestations in Inflammatory Bowel Disease: A Cohort Study During the Biologic Era

Med Sci Monit In Press; DOI: 10.12659/MSM.936497  

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750