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22 June 2024 : Clinical Research  

Shortening Oral Simethicone-to-Colonoscopy Interval Increases Bowel Preparation Quality

Rongrong Cao1BCDEF, Fanjun Meng1BCD, Chengkun Li1B, Hongxin Chen1E, Cong Gao1B, Hongyu Li1E, Xingshun Qi1ABCDEFG*

DOI: 10.12659/MSM.943972

Med Sci Monit 2024; 30:e943972



BACKGROUND: Simethicone can improve bowel preparation quality, but the optimal timing of oral simethicone before colonoscopy has not been determined. This study aimed to explore the effect of the time interval between oral simethicone and the start of colonoscopy (S-C) on bowel preparation quality.

MATERIAL AND METHODS: A total of 364 patients undergoing colonoscopy at our department from August 1, 2021 to November 30, 2021 were included in the training cohort, and 420 consecutive patients from December 15, 2021 to January 31, 2022 comprised the validation cohort. They were classified into short and long S-C groups according to the median S-C. Bowel preparation quality evaluated by the Boston Bowel Preparation Scale was compared between the 2 groups. Logistic regression analyses were performed to explore the correlation between S-C and bowel preparation quality, and we explored the effect of run-way time and time of starting colonoscopy on bowel preparation quality.

RESULTS: In the training cohort, 182 and 182 patients were classified into the short and long S-C groups, respectively; in the validation cohort, 210 and 210 patients were classified into the 2 groups, respectively. In the 2 cohorts, the short S-C group had a significantly higher rate of adequate/excellent bowel preparation than the long S-C group. Logistic regression analyses showed that shorter S-C, shorter run-way time, and colonoscopy in the morning were all correlated with adequate/excellent bowel preparation.

CONCLUSIONS: Bowel preparation quality may be affected by S-C, run-way time, and time of starting colonoscopy. S-C shortening should be given equal importance as run-way time shortening.

Keywords: Simethicone, Colonoscopy, endoscopy

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750