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27 June 2024 : Clinical Research  

Elevated Plasma Levels of Growth Arrest Specific 6 (Gas6) Protein in Severe Obesity: Implications for Adipose Tissue and Inflammation

Daniele Sola1CDEFG*, Mattia Bellan1ABCDEF, Stefania Mai2ABCDE, Rosalba Minisini3CD, Mattia Perazzi4E, Amelia Brunani2ABCD, Sergio Gentilli5E, Pier Paolo Sainaghi1E, Massimo Scacchi6ABCD, Paolo Marzullo1ABCDF

DOI: 10.12659/MSM.944462

Med Sci Monit 2024; 30:e944462

Abstract

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BACKGROUND: Preliminary data suggest an adipogenic role for growth arrest-specific 6 (Gas6), a pleiotropic molecule involved in inflammation, proliferation, and hemostasis through its Tyro3, Axl, and MerTK (TAM) receptors. This study compares Gas6 expression in plasma and visceral and subcutaneous adipose tissue in 42 adults with obesity (body mass index ≥40 kg/m²) and 32 normal-weight controls to elucidate its role in obesity and related metabolic alterations.

MATERIAL AND METHODS: Using a case-control design, we measured Gas6 levels in plasma via a validated sandwich enzyme-linked immunosorbent assay and in adipose tissues through quantitative polymerase chain reactio with specific probes. Medians and correlations were analyzed using Mann-Whitney and Spearman tests. A general linear model assessed the impact of covariates on the Gas6-anthropometric relationship, with statistical significance determined by P values.

RESULTS: Plasma Gas6 levels were significantly higher in the obese group than in controls (P=0.0006). While Gas6 mRNA expression did not significantly differ in subcutaneous adipose tissue between groups, it was notably higher in visceral than subcutaneous adipose tissue in controls (P<0.05). A significant correlation was found between plasma Gas6 levels and body mass index (P=0.001).

CONCLUSIONS: Gas6 plasma levels are elevated in morbid obesity, particularly in visceral adipose tissue, and are linked to altered glucose tolerance in female patients. These findings highlight the role of Gas6 in obesity-related metabolic complications and suggest avenues for further research and potential therapies.

Keywords: Obesity, Adipose Tissue, Intra-Abdominal Fat, FTO Protein, Human, Abdominal Obesity Metabolic Syndrome, Growth Arrest-Specific Protein 6

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750