30 June 2014 : Original article
Monocyte chemoattractant protein-1 gene (MCP-1-2518 A/G) polymorphism and serological markers of hepatitis B virus infection in hemodialysis patients
Alicja E. Grzegorzewska ABCDEFG , Dominik Pajzderski BCE , Anna Sowińska C , Paweł P. Jagodziński ACGDOI: 10.12659/MSM.891009
Med Sci Monit 2014; 20:1101-1116
Supplementary Table 2 Comparison of the distribution of MCP1 rs1024611 polymorphic variants in anti-HBc negative and anti-HBc positive HD without or with DM.
| Genotype | HD patients anti-HBc negative (frequency) | HD patients anti-HBc positive (frequency) | Odds ratio (95%CI) | Two-tailed P | Ptrend | Pgenotyping | Power (%) |
|---|---|---|---|---|---|---|---|
| All HD patients | |||||||
| n=754 | n=170 | ||||||
| AA | 349 (0.46) | 87 (0.51) | Referent | – | 0.718 | 0.122 | |
| AG | 352 (0.47) | 66 (0.39) | 0.752 (0.520–1.086) | 0.134 | 35.0 | ||
| GG | 53 (0.07) | 17 (0.10) | 1.287 (0.664–2.392) | 0.493 | 12.0 | ||
| AG+GG | 405 (0.54) | 83 (0.49) | 0.822 (0.581–1.163) | 0.285 | 19.4 | ||
| MAF | 458 (0.30) | 100 (0.29) | 0.955 (0.730–1.244) | 0.781 | 5.6 | ||
| AA | 245 (0.46) | 66 (0.54) | Referent | – | 0.493 | ||
| AG | 255 (0.48) | 44 (0.36) | 0.641 (0.410–0.994) | 0.047 | 53.6 | ||
| GG | 32 (0.06) | 12 (0.10) | 1.392 (0.617–2.961) | 0.468 | 13.4 | ||
| AG+GG | 287 (0.54) | 56 (0.46) | 0.724 (0.478–1.096) | 0.133 | 34.3 | ||
| MAF | 319 (0.30) | 68 (0.28) | 0.902 (0.652–1.240) | 0.569 | 9.0 | ||
| AA | 104 (0.47) | 21 (0.44) | Referent | – | 0.696 | 0.923 | |
| AG | 97 (0.44) | 22 (0.46) | 1.123 (0.550–2.296) | 0.858 | 5.6 | ||
| GG | 21 (0.09) | 5 (0.10) | 1.179 (0.312–3.721) | 0.956 | 5.2 | ||
| AG+GG | 118 (0.53) | 27 (0.56) | 1.133 (0.603–2.245) | 0.820 | 5.2 | ||
| MAF | 139 (0.31) | 32 (0.33) | 1.097 (0.662–1.791) | 0.783 | 6.0 | ||
| anti-HBc – antibodies to core antigen of hepatitis B virus; DM – diabetes mellitus, hemodialysis; HD – hemodialysis; MAF – minor allele frequency. Significant differences are indicated using bold font. | |||||||