21 September 2015 : Laboratory Research
Variation in DNA Base Excision Repair Genes in Fuchs Endothelial Corneal Dystrophy
Katarzyna A. Wójcik BCDEF , Ewelina Synowiec BCDF , Piotr Polakowski D , Janusz Błasiak AEF , Jerzy Szaflik AFG , Jacek P. Szaflik AEGDOI: 10.12659/MSM.894273
Med Sci Monit 2015; 21:2809-2827
Supplementary Table 6. Distribution of combined genotypes of the c.2285T>C – PARP-1 and c.580C>T – XRCC1 polymorphisms and odds ratio (OR) with 95% confidence interval (95% CI) in patients with Fuchs endothelial corneal dystrophy (FECD) and controls.
| Combined genotypes | Controls (n=353) | FECD (n=250) | Crude OR (95% CI) | p | Adjusted OR* (95% CI) | p |
|---|---|---|---|---|---|---|
| Number (frequency) | ||||||
| A/A – C/C | 204 (0.58) | 150 (0.60) | 1.18 (0.84–1.65) | 0.344 | 1.22 (0.82–1.80) | 0.329 |
| A/A – C/T | 35 (0.10) | 16 (0.06) | 0.58 (0.31–1.08) | 0.086 | 1.43 (0.92–2.21) | 0.084 |
| A/A – T/T | 0 (0.00) | 0 (0.00) | – | |||
| A/G – C/C | 101 (0.29) | 73 (0.29) | 0.99 (0.69–1.43) | 0.963 | 0.99 (0.65–1.53) | 0.994 |
| A/G – C/T | 13 (0.04) | 11 (0.04) | 1.10 (0.48–2.49) | 0.824 | 0.99 (0.39–2.49) | 0.982 |
| A/G – T/T | 0 (0.00) | 0 (0.00) | – | – | – | – |
| G/G – C/C | 0 (0.00) | 0 (0.00) | – | – | – | – |
| G/G – C/T | 0 (0.00) | 0 (0.00) | – | – | – | – |
| G/G – T/T | 0 (0.00) | 0 (0.00) | – | – | – | – |
| values * OR adjusted for co-occurrence of visual impairment, sex, age and family history for FECD. | ||||||