21 September 2015 : Laboratory Research
Variation in DNA Base Excision Repair Genes in Fuchs Endothelial Corneal Dystrophy
Katarzyna A. Wójcik BCDEF , Ewelina Synowiec BCDF , Piotr Polakowski D , Janusz Błasiak AEF , Jerzy Szaflik AFG , Jacek P. Szaflik AEGDOI: 10.12659/MSM.894273
Med Sci Monit 2015; 21:2809-2827
Supplementary Table 8. Distribution of combined genotypes of the c.–1370T>A – POLG and c.580C>T – XRCC1 polymorphisms and odds ratio (OR) with 95% confidence interval (95% CI) in patients with Fuchs endothelial corneal dystrophy (FECD) and controls.
| Combined genotypes | Controls (n=353) | FECD (n=250) | Crude OR (95% CI) | p | Adjusted OR* (95% CI) | p |
|---|---|---|---|---|---|---|
| Number (frequency) | ||||||
| A/A – C/C | 41 (0.12) | 32 (0.13) | 1.12 (0.68–1.83) | 0.660 | 1.07 (0.61–1.88) | 0.804 |
| A/A – C/T | 5 (0.01) | 3 (0.01) | 0.84 (0.20–3.57) | 0.819 | 1.38 (0.90–2.13) | 0.745 |
| A/A – T/T | 0 (0.00) | 0 (0.00) | – | – | ||
| A/T – C/C | 175 (0.50) | 130 (0.52) | 1.10 (0.80–1.52) | 0.557 | 1.39 (0.92–1.96) | 0.129 |
| A/T – C/T | 28 (0.08) | 14 (0.06) | 0.70 (0.35–1.33) | 0.270 | 0.81 (0.36–1.80) | 0.601 |
| A/T – T/T | 0 (0.00) | 0 (0.00) | – | – | – | – |
| T/T – C/C | 89 (0.25) | 61 (0.24) | 0.96 (0.66–1.39) | 0.820 | 0.69 (0.44–1.09) | 0.110 |
| T/T – C/T | 15 (0.04) | 10 (0.04) | 0.94 (0.41–2.13) | 0.880 | 0.85 (0.32–2.20) | 0.732 |
| T/T – T/T | 0 (0.00) | 0 (0.00) | – | – | – | – |
| values * OR adjusted for co-occurrence of visual impairment, sex, age and family history for FECD. | ||||||