21 September 2015 : Laboratory Research
Variation in DNA Base Excision Repair Genes in Fuchs Endothelial Corneal Dystrophy
Katarzyna A. Wójcik BCDEF , Ewelina Synowiec BCDF , Piotr Polakowski D , Janusz Błasiak AEF , Jerzy Szaflik AFG , Jacek P. Szaflik AEGDOI: 10.12659/MSM.894273
Med Sci Monit 2015; 21:2809-2827
Supplementary Table 9. Distribution of combined genotypes of the c.–1370T>A – POLG and c.1196A>G – XRCC1 polymorphisms and odds ratio (OR) with 95% confidence interval (95% CI) in patients with Fuchs endothelial corneal dystrophy (FECD) and controls.
| Combined genotypes | Controls (n=353) | FECD (n=250) | Crude OR (95% CI) | p | Adjusted OR* (95% CI) | p |
|---|---|---|---|---|---|---|
| Number (frequency) | ||||||
| A/A – A/A | 6 (0.02) | 14 (0.06) | ||||
| A/A – A/G | 31 (0.09) | 18 (0.07) | 0.81 (0.44–1.48) | 0.484 | 0.71 (0.35–1.44) | 0.344 |
| A/A – G/G | 9 (0.03) | 3 (0.01) | 0.46 (0.12–1.73) | 0.253 | ||
| A/T – A/A | 41 (0.12) | 43 (0.17) | 1.58 (0.99–2.51) | 0.052 | 1.65 (0.97–2.80) | 0.066 |
| A/T – A/G | 118 (0.33) | 88 (0.35) | 1.08 (0.77–1.52) | 0.651 | 1.27 (0.84–1.85) | 0.274 |
| A/T – G/G | 44 (0.12) | 13 (0.05) | 0.49 (0.24–1.03) | 0.060 | ||
| T/T – A/A | 25 (0.07) | 17 (0.07) | 0.96 (0.50–1.81) | 0.893 | 0.84 (0.42–1.67) | 0.615 |
| T/T – A/G | 69 (0.20) | 37 (0.15) | 0.71 (0.46–1.11) | 0.132 | ||
| T/T – G/G | 10 (0.03) | 17 (0.07) | 2.50 (1.13–5.56) | 0.024 | 1.70 (0.64–4.50) | 0.283 |
| values * OR adjusted for co-occurrence of visual impairment, sex, age and family history for FECD. | ||||||