21 September 2015 : Laboratory Research
Variation in DNA Base Excision Repair Genes in Fuchs Endothelial Corneal Dystrophy
Katarzyna A. Wójcik BCDEF , Ewelina Synowiec BCDF , Piotr Polakowski D , Janusz Błasiak AEF , Jerzy Szaflik AFG , Jacek P. Szaflik AEGDOI: 10.12659/MSM.894273
Med Sci Monit 2015; 21:2809-2827
Supplementary Table 1. Distribution of combined genotypes of the g.46438521G>C – NEIL1 and c.2285T>C – PARP-1 polymorphisms and odds ratio (OR) with 95% confidence interval (95% CI) in patients with Fuchs endothelial corneal dystrophy (FECD) and controls.
| Combined genotypes | Controls (n=353) | FECD (n=250) | Crude OR (95% CI) | p | Adjusted OR* (95% CI) | p |
|---|---|---|---|---|---|---|
| Number (frequency) | ||||||
| C/C – A/A | 64 (0.18) | 35 (0.14) | 0.73 (0.47–1.15) | 0.178 | 0.90 (0.53–1.53) | 0.702 |
| C/C – A/G | 34 (0.10) | 18 (0.07) | 0.73 (0.40–1.32) | 0.296 | ||
| C/C – G/G | 0 (0.00) | 0 (0.00) | – | – | – | – |
| C/G – A/A | 167 (0.47) | 126 (0.50) | 1.13 (0.82–1.56) | 0.454 | 1.11 (0.76–1.62) | 0.595 |
| C/G – A/G | 73 (0.21) | 62 (0.25) | 1.26 (0.86–1.86) | 0.232 | 1.42 (0.91–2.25) | 0.122 |
| C/G – G/G | 0 (0.00) | 0 (0.00) | – | – | – | – |
| G/G – A/A | 8 (0.02) | 5 (0.02) | 0.88 (0.28–2.73) | 0.825 | 1.38 (0.90–2.11) | 0.924 |
| G/G – A/G | 7 (0.02) | 4 (0.02) | 0.80 (0.23–2.77) | 0.730 | 0.53 (0.13–2.15) | 0.376 |
| G/G – G/G | 0 (0.00) | 0 (0.00) | – | – | – | – |
| values * OR adjusted for co-occurrence of visual impairment, sex, age and family history for FECD. | ||||||