21 September 2015 : Laboratory Research
Variation in DNA Base Excision Repair Genes in Fuchs Endothelial Corneal Dystrophy
Katarzyna A. Wójcik BCDEF , Ewelina Synowiec BCDF , Piotr Polakowski D , Janusz Błasiak AEF , Jerzy Szaflik AFG , Jacek P. Szaflik AEGDOI: 10.12659/MSM.894273
Med Sci Monit 2015; 21:2809-2827
Supplementary Table 3. Distribution of combined genotypes of the g.46438521G>C – NEIL1 and c.580C>T – XRCC1 polymorphisms and odds ratio (OR) with 95% confidence interval (95% CI) in patients with Fuchs endothelial corneal dystrophy (FECD) and controls.
| Combined genotypes | Controls (n=353) | FECD (n=250) | Crude OR (95% CI) | p | Adjusted OR* (95% CI) | p |
|---|---|---|---|---|---|---|
| Number (frequency) | ||||||
| C/C – C/C | 82 (0.23) | 49 (0.20) | 0.81 (0.54–1.20) | 0.287 | 0.73 (0.46–1.17) | 0.193 |
| C/C – C/T | 16 (0.05) | 4 (0.02) | 0.34 (0.11–1.04) | 0.058 | 0.33 (0.08–1.32) | 0.118 |
| C/C – T/T | 0 (0.00) | 0 (0.00) | – | – | – | – |
| C/G – C/C | 210 (0.59) | 167 (0.67) | 1.37 (0.98–1.92) | 0.068 | 1.42 (0.95–2.10) | 0.084 |
| C/G – C/T | 30 (0.08) | 21 (0.08) | 0.99 (0.55–1.77) | 0.966 | 1.09 (0.55–2.16) | 0.809 |
| C/G – T/T | 0 (0.00) | 0 (0.00) | – | – | – | – |
| G/G – C/C | 13 (0.04) | 7 (0.03) | 0.75 (0.30–1.92) | 0.552 | 0.67 (0.24–1.89) | 0.452 |
| G/G – C/T | 2 (0.01) | 2 (0.01) | 1.41 (0.20–10.11) | 0.729 | 1.45 (0.16–12.87) | 0.735 |
| G/G – T/T | 0 (0.00) | 0 (0.00) | – | – | – | – |
| values * OR adjusted for co-occurrence of visual impairment, sex, age and family history for FECD. | ||||||