21 September 2015 : Laboratory Research
Variation in DNA Base Excision Repair Genes in Fuchs Endothelial Corneal Dystrophy
Katarzyna A. Wójcik BCDEF , Ewelina Synowiec BCDF , Piotr Polakowski D , Janusz Błasiak AEF , Jerzy Szaflik AFG , Jacek P. Szaflik AEGDOI: 10.12659/MSM.894273
Med Sci Monit 2015; 21:2809-2827
Supplementary Table 4. Distribution of combined genotypes of the g.46438521G>C – NEIL1 and c.1196A>G – XRCC1 polymorphisms and odds ratio (OR) with 95% confidence interval (95% CI) in patients with Fuchs endothelial corneal dystrophy (FECD) and controls.
| Combined genotypes | Controls (n=353) | FECD (n=250) | Crude OR (95% CI) | p | Adjusted OR* (95% CI) | p |
|---|---|---|---|---|---|---|
| Number (frequency) | ||||||
| C/C – A/A | 24 (0.07) | 16 (0.06) | 0.93 (0.48–1.80) | 0.846 | 1.05 (0.50–2.20) | 0.903 |
| C/C – A/G | 59 (0.17) | 29 (0.12) | 0.65 (0.41–1.05) | 0.081 | 0.56 (0.31–1.01) | 0.054 |
| C/C – G/G | 15 (0.04) | 8 (0.03) | 0.74 (0.31–1.78) | 0.509 | 0.65 (0.23–1.85) | 0.417 |
| C/G – A/A | 48 (0.14) | 55 (0.22) | 1.61 (0.99–2.62) | 0.053 | ||
| C/G – A/G | 146 (0.41) | 108 (0.43) | 1.08 (0.77–1.50) | 0.652 | 1.14 (0.78–1.68) | 0.477 |
| C/G – G/G | 46 (0.13) | 25 (0.10) | 0.74 (0.44–1.24) | 0.256 | 0.81 (0.43–1.53) | 0.525 |
| G/G – A/A | 0 (0.00) | 3 (0.01) | – | – | ||
| G/G – A/G | 13 (0.04) | 6 (0.02) | 0.64 (0.24–1.72) | 0.378 | 0.49 (0.16–1.47) | 0.205 |
| G/G – G/G | 2 (0.01) | 0 (0.00) | – | – | – | – |
| values * OR adjusted for co-occurrence of visual impairment, sex, age and family history for FECD. | ||||||