21 September 2015 : Laboratory Research
Variation in DNA Base Excision Repair Genes in Fuchs Endothelial Corneal Dystrophy
Katarzyna A. Wójcik BCDEF , Ewelina Synowiec BCDF , Piotr Polakowski D , Janusz Błasiak AEF , Jerzy Szaflik AFG , Jacek P. Szaflik AEGDOI: 10.12659/MSM.894273
Med Sci Monit 2015; 21:2809-2827
Supplementary Table 5. Distribution of combined genotypes of the c.2285T>C – PARP-1 and c.–1370T>A – POLG polymorphisms and odds ratio (OR) with 95% confidence interval (95% CI) in patients with Fuchs endothelial corneal dystrophy (FECD) and controls.
| Combined genotypes | Controls (n=353) | FECD (n=250) | Crude OR (95% CI) | p | Adjusted OR* (95% CI) | p |
|---|---|---|---|---|---|---|
| Number (frequency) | ||||||
| A/A – A/A | 29 (0.08) | 26 (0.10) | 1.30 (0.74–2.61) | 0.360 | 1.16 (0.62–2.18) | 0.645 |
| A/A – A/T | 17 (0.05) | 9 (0.04) | 0.74 (0.32–1.68) | 0.470 | 0.96 (0.38–2.43) | 0.929 |
| A/A – T/T | 0 (0.00) | 0 (0.00) | – | – | – | – |
| A/G – A/A | 143 (0.41) | 104 (0.42) | 1.05 (0.75–1.45) | 0.789 | 1.33 (0.90–1.95) | 0.150 |
| A/G – A/T | 60 (0.17) | 40 (0.16) | 0.93 (0.60–1.44) | 0.746 | 0.95 (0.57–1.58) | 0.849 |
| A/G – T/T | 0 (0.00) | 0 (0.00) | – | – | – | – |
| G/G – A/A | 67 (0.19) | 36 (0.14) | 0.72 (0.46–1.12) | 0.142 | 0.61 (0.37–1.03) | 0.065 |
| G/G – A/T | 37 (0.10) | 35 (0.14) | 1.39 (0.85–2.28) | 0.191 | 0.94 (0.52–1.74) | 0.867 |
| G/G – T/T | 0 (0.00) | 0 (0.00) | – | – | – | – |
| values * OR adjusted for co-occurrence of visual impairment, sex, age and family history for FECD. | ||||||