29 November 2015 : Meta-Analysis
Efficacy of Ligustrazine Injection as Adjunctive Therapy for Angina Pectoris: A Systematic Review and Meta-Analysis
Huikai Shao ABCEF , Lingguo Zhao ACEG , Fuchao Chen CD , Shengbo Zeng E , Shengquan Liu BC , Jiajia Li BCDOI: 10.12659/MSM.895362
Med Sci Monit 2015; 21:3704-3715
Supplementary Table 1 Summary of the included studies evaluating the adjunctive therapy of ligustrazine injection in treating angina.
| Study | Year | Country | Age | Intervention | Sample | Follow-up (day) | Outcome measures | |
|---|---|---|---|---|---|---|---|---|
| Treatment | Control | |||||||
| Da MF | 2008 | China | 41–83 | Ligustrazine injection 80 mg/d, Nitroglycerin 10–15 mg/d, Aspirin 100 mg/d, Metoprolol 50 mg/d | Nitroglycerin 10–15 mg/d, Aspirin 100 mg/d, Metoprolol 50 mg/d | 74 | 14 | SYM, ECG |
| Ji ZJ | 2009 | China | 29–52 | Ligustrazine injection 100 mg/d, Aspirin 100 mg/d, Isosorbide dinitrate 30 mg/d, Simvastatin 40 mg/d, Isosorbide-5-mononitrate 20 mg/d | Aspirin 100 mg/d, Isosorbide dinitrate 30 mg/d, Simvastatin 40 mg/d, Isosorbide-5-mononitrate 20 mg/d | 80 | 14 | SYM |
| Li Y | 2010 | China | 42–76 | Ligustrazine injection 120 mg/d, Nitroglycerin 10–15 mg/d, Aspirin 100 mg/d, Metoprolol 50 mg/d | Nitroglycerin 10–15 mg/d, Aspirin 100 mg/d, Metoprolol 50 mg/d | 68 | 14 | SYM |
| Liao JQ | 2006 | China | 46–71 | Ligustrazine injection 120 mg/d, Nitroglycerin 50 mg/d, Aspirin 150 mg/d | Nitroglycerin 50 mg/d, Aspirin 150 mg/d | 68 | 14 | SYM |
| Liu YJ | 2009 | China | 42–70 | Ligustrazine injection 150 mg/d, Isosorbide-5-mononitrate 60 mg/d | Isosorbide-5-mononitrate 60 mg/d | 97 | 28 | SYM, ECG |
| Luo B | 2007 | China | 44–78 | Ligustrazine injection 100 mg/d, Nitroglycerin 10 mg/d, Aspirin 75 mg/d | Nitroglycerin 10 mg/d, Aspirin 75 mg/d | 80 | 14 | SYM |
| Sun DN | 2007 | China | 48–80 | Ligustrazine injection 120–200 mg/d, Isosorbide dinitrate 30 mg/d, Nitroglycerin 0.3–0.6 mg/d, Aspirin 100 mg/d | Isosorbide dinitrate 30 mg/d, Nitroglycerin 0.3–0.6 mg/d, Aspirin 100 mg/d | 96 | 21 | SYM, ECG |
| Wang QZ | 2008 | China | 48–80 | Ligustrazine injection 80 mg/d, Aspirin 75 mg/d, Nitroglycerin 0.3–0.6 mg/d | Aspirin 75 mg/d, Nitroglycerin 0.3–0.6 mg/d | 84 | 14 | SYM, ECG |
| Wang XY | 2008 | China | 44–79 | Ligustrazine injection 150 mg/d, Isosorbide-5-mononitrate 60 mg/d | Isosorbide-5-mononitrate 60 mg/d | 64 | 14 | SYM, ECG |
| Yang JX | 2008 | China | 46–78 | Ligustrazine injection 100 mg/d, Isosorbide dinitrate 30 mg/d, Aspirin 75 mg/d, Nitroglycerin 0.3–0.6 mg/d | Isosorbide dinitrate 30 mg/d, Aspirin 75 mg/d, Nitroglycerin 0.3–0.6 mg/d | 50 | 14 | ECG |
| Yao MJ | 2009 | China | 43–74 | Ligustrazine injection 240 mg/d, Aspirin 100 mg/d, Isosorbide dinitrate 30 mg/d | Aspirin 100 mg/d, Isosorbide dinitrate 30 mg/d | 120 | 15 | SYM, ECG |