06 September 2020 : Laboratory Research
The rs6427384 and rs6692977 Single Nucleotide Polymorphisms of the Fc Receptor-Like 5 (FCRL5) Gene and the Risk of Ankylosing Spondylitis: A Case Control Study in a Single Center in China
Hua-Wei Liu1A, Dai-Xu Wei2AB, Da-Wei He1AD, Jiu-Zheng Deng1DE, Jian-Jin Zhu1DE, Kai Xu1AD, Dong Hu1DF, Jing Li3BDF, Wen-Hao Hu3ACF, Yan Wang3BDE, Song-Hua Xiao1EFG, Li-Gong Fu1ACDE*DOI: 10.12659/MSM.920956
Med Sci Monit 2020; 26:e920956
Table 2 Comparison of the genotype and allele distributions of FCRL5 gene rs6427384 and rs6692977 polymorphisms between case and control groups.
| SNPs | Genotype/allele | Case (%) (n=130) | Control (%) (n=135) | χ2 | P | OR (95% CI) |
|---|---|---|---|---|---|---|
| rs6427384 | TT | 93 (68.89) | 78 (60.00) | – | – | 1 |
| CT | 38 (28.15) | 41 (31.54) | 0.856 | 0.355 | 0.777 (0.456–1.326) | |
| CC | 4 (2.96) | 11 (8.46) | 4.246 | 0.039 | 0.305 (0.093–0.996) | |
| T | 224 (82.96) | 197 (75.77) | – | – | 1 | |
| C | 46 (17.04) | 63 (24.23) | 4.196 | 0.041 | 0.642 (0.420–0.983) | |
| rs6692977 | CC | 102 (78.46) | 109 (80.74) | – | – | 1 |
| CT | 25 (19.23) | 26 (19.26) | 0.008 | 0.931 | 1.028 (0.557–1.895) | |
| TT | 3 (2.31) | 0 (0.00) | 3.159 | 0.076 | 0.971 (0.940–1.004) | |
| C | 229 (88.08) | 244 (90.37) | – | – | 1 | |
| T | 31 (11.92) | 26 (9.63) | 0.726 | 0.394 | 1.270 (0.732–2.205) | |
| FCRL5 – Fc receptor-like 5; SNP – single nucleotide polymorphism; OR – odds ratio; CI – confidence interval. | ||||||