22 June 2020: Database Analysis
Predictive Nomogram for Midterm to Long-Term Prognosis in Patients with Papillary Renal Cell Carcinoma Based on Data from the Surveillance, Epidemiology, and End Results (SEER) Program
Haosheng Wang BCDF , Xueliang Cheng G , Jianwu Zhao F , Mingyang Kang BF , Rongpeng Dong BC , Kai Wang B , Yang Qu AEFG*DOI: 10.12659/MSM.921859
Med Sci Monit 2020; 26:e921859
Table 2 Univariate and multivariate Cox regression model analysis of overall survival (OS) in the training cohort.
| Variables | Univariate Cox model | P-value | Multivariate Cox model | P-value | ||
|---|---|---|---|---|---|---|
| Overall survival | Overall survival | |||||
| HR | 95% CI | HR | 95% CI | |||
| Age (years)) | ||||||
| 1 (Reference) | 1 (Reference) | |||||
| 40–49 | 1.14 | 0.781–1.664 | 0.498 | 1.335 | 0.914–1.952 | 0.135504 |
| 50–59 | 1.425 | 1.005–2.020 | 0.047* | 1.730 | 1.219–2.458 | 0.002169** |
| 60–69 | 2.025 | 1.439–2.848 | 5.08e-05*** | 2.513 | 1.783–3.542 | 1.41e-07*** |
| 70–79 | 3.319 | 2.360–4.669 | 5.57e-12*** | 3.977 | 2.821–5.607 | 3.39e-15*** |
| ≥80 | 6.045 | 4.256–8.587 | *** | 5.964 | 4.189–8.491 | *** |
| Gender | ||||||
| Female | 1 (Reference) | |||||
| Male | 1.06 | 0.9522–1.181 | 0.286 | |||
| Race | ||||||
| White | 1 (Reference) | |||||
| Black/African-American | 1.044 | 0.945–1.154 | 0.4 | |||
| Others | 0.8347 | 0.622–1.120 | 0.228 | |||
| Grade | ||||||
| I | 1 (Reference) | 1 (Reference) | ||||
| II | 1.057 | 0.525 | 1.093 | 0.920–1.300 | 0.312058 | |
| III | 1.59 | 1.335–1.894 | 1.95e-07*** | 1.341 | 1.120–1.605 | 0.001410** |
| IV | 3.685 | 2.925–4.643 | *** | 1.991 | 1.562–2.536 | 2.53e-08*** |
| Unknown | 1.63 | 1.361–1.952 | 1.15e-07*** | 1.280 | 1.065–1.539 | 0.008616** |
| T | 1.63 | |||||
| T1 | 1 (Reference) | 1 (Reference) | ||||
| T2 | 1.779 | 1.564–2.024 | *** | 1.262 | 1.103–1.444 | 0.000724*** |
| T3 | 2.737 | 2.434–3.077 | *** | 1.549 | 1.356–1.770 | 1.20e-10*** |
| T4 | 7.103 | 5.139–9.817 | *** | 1.405 | 0.983–2.008 | 0.062421 |
| TX | 4.824 | 3.491–6.666 | *** | 1.649 | 1.152–2.359 | 0.006237** |
| N | ||||||
| N0 | 1 (Reference) | 1 (Reference) | ||||
| N1 | 6.383 | 5.312–7.670 | *** | 2.182 | 1.729–2.753 | 5.01e-11*** |
| N2 | 7.936 | 6.494–9.698 | *** | 2.207 | 1.554–2.643 | 1.83e-07*** |
| NX | 1.598 | 1.180–2.163 | 0.00242** | 1.184 | 0.834–1.679 | 0.344867 |
| M | ||||||
| M0 | 1 (Reference) | 1 (Reference) | ||||
| M1 | 11.212 | 9.711–12.945 | *** | 3.989 | 3.268–4.869 | *** |
| MX | 1.547 | 0.984–2.431 | 0.059 | 0.991 | 0.587–1.674 | 0.972989 |
| Surgery of primary site | ||||||
| None | 1 (Reference) | |||||
| Partial nephrectomy | 0.131 | 0.110–0.156 | 0.316 | 0.256–0.389 | *** | |
| Total nephrectomy | 0.329 | 0.281–0.384 | 0.612 | 0.502–0.746 | 1.14e-06*** | |
| Lymphadenectomy, num | ||||||
| 0 | 1 (Reference) | 1 (Reference) | ||||
| 1–3 regional lymph nodes | 1.844 | 1.565–2.173 | 2.82e-13*** | 1.024 | 0.848–1.235 | 0.807307 |
| ≥4 regional lymph nodes | 2.138 | 5.84e-16*** | 0.987 | 0.793–1.228 | 0.906166 | |
| Chemotherapy | ||||||
| No/Unknown | 1 (Reference) | 1.778–2.570 | 1 (Reference) | |||
| Yes | 7.244 | 6.180–8.491 | *** | 1.448 | 1.170–1.791 | 0.000662*** |
| Marital status | ||||||
| Single | 1 (Reference) | 1 (Reference) | ||||
| Married | 0.7713 | 0.704–0.846 | 3.03e-08*** | 0.752 | 0.684–0.825 | 2.17e-09*** |
| SEER – Surveillance, Epidemiology, and End Results; HR – hazard ratio; CI – confidence interval. p * p ** p *** p | ||||||