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22 June 2020: Database Analysis

Predictive Nomogram for Midterm to Long-Term Prognosis in Patients with Papillary Renal Cell Carcinoma Based on Data from the Surveillance, Epidemiology, and End Results (SEER) Program

Haosheng Wang BCDF , Xueliang Cheng G , Jianwu Zhao F , Mingyang Kang BF , Rongpeng Dong BC , Kai Wang B , Yang Qu AEFG*

DOI: 10.12659/MSM.921859

Med Sci Monit 2020; 26:e921859

Table 2 Univariate and multivariate Cox regression model analysis of overall survival (OS) in the training cohort.

VariablesUnivariate Cox modelP-valueMultivariate Cox modelP-value
Overall survivalOverall survival
HR95% CIHR95% CI
Age (years))
1 (Reference)1 (Reference)
 50–591.4251.005–2.0200.047* 1.7301.219–2.4580.002169**
 60–692.0251.439–2.8485.08e-05*** 2.5131.783–3.5421.41e-07***
 70–793.3192.360–4.6695.57e-12*** 3.9772.821–5.6073.39e-15***
 ≥806.0454.256–8.587*** 5.9644.189–8.491***
 Female1 (Reference)
 White1 (Reference)
 I1 (Reference)1 (Reference)
 III1.591.335–1.8941.95e-07*** 1.3411.120–1.6050.001410**
 IV3.6852.925–4.643*** 1.9911.562–2.5362.53e-08***
 Unknown1.631.361–1.9521.15e-07*** 1.2801.065–1.5390.008616**
 T11 (Reference)1 (Reference)
 T21.7791.564–2.024*** 1.2621.103–1.4440.000724***
 T32.7372.434–3.077*** 1.5491.356–1.7701.20e-10***
 T47.1035.139–9.817*** 1.4050.983–2.0080.062421
 TX4.8243.491–6.666*** 1.6491.152–2.3590.006237**
 N01 (Reference)1 (Reference)
 N16.3835.312–7.670*** 2.1821.729–2.7535.01e-11***
 N27.9366.494–9.698*** 2.2071.554–2.6431.83e-07***
 NX1.5981.180–2.1630.00242** 1.1840.834–1.6790.344867
 M01 (Reference)1 (Reference)
 M111.2129.711–12.945*** 3.9893.268–4.869***
Surgery of primary site
 None1 (Reference)
 Partial nephrectomy0.1310.110–0.1560.3160.256–0.389***
 Total nephrectomy0.3290.281–0.3840.6120.502–0.7461.14e-06***
Lymphadenectomy, num
 01 (Reference)1 (Reference)
 1–3 regional lymph nodes1.8441.565–2.1732.82e-13*** 1.0240.848–1.2350.807307
 ≥4 regional lymph nodes2.1385.84e-16*** 0.9870.793–1.2280.906166
No/Unknown1 (Reference)1.778–2.5701 (Reference)
Yes7.2446.180–8.491*** 1.4481.170–1.7910.000662***
Marital status
 Single1 (Reference)1 (Reference)
 Married0.77130.704–0.8463.03e-08*** 0.7520.684–0.8252.17e-09***
SEER – Surveillance, Epidemiology, and End Results; HR – hazard ratio; CI – confidence interval. p
* p
** p
*** p

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750