Involvement of p53, p21, and Caspase-3 in Apoptosis of Coronary Artery Smooth Muscle Cells in a Kawasaki Vasculitis Mouse Model

Minghong Deng; Chunwang Lin; Xianglin Zeng; Jianping Zhang; Fang Wen; Ziguang Liu; Haiyan Wu; Xiaofeng Wu

doi:10.12659/MSM.922429

21 August 2020 : Animal Research

Involvement of p53, p21, and Caspase-3 in Apoptosis of Coronary Artery Smooth Muscle Cells in a Kawasaki Vasculitis Mouse Model

Minghong Deng^1ACE, Chunwang Lin^1AE*, Xianglin Zeng^1C, Jianping Zhang^1BD, Fang Wen^1C, Ziguang Liu^2B, Haiyan Wu^3B, Xiaofeng Wu^4B

DOI: 10.12659/MSM.922429

Med Sci Monit 2020; 26:e922429

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Table 1 Comparison of IRS values for p53, p21, Bcl2, and caspase-3 between the KD and control groups.

Group	n	p53 IRS	p21 IRS	Bcl2 IRS	Caspase-3 IRS
KD	12	5.33±0.90	5.07±0.70	4.43±0.51	5.60±0.50
Control	12	4.05±1.05	3.21±0.97	6.37±0.76	3.83±0.38
		4.61	5.30	5.79	5.24
		0.001	0.001	0.001	0.001

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Involvement of p53, p21, and Caspase-3 in Apoptosis of Coronary Artery Smooth Muscle Cells in a Kawasaki Vasculitis Mouse Model

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