Involvement of p53, p21, and Caspase-3 in Apoptosis of Coronary Artery Smooth Muscle Cells in a Kawasaki Vasculitis Mouse Model

21 August 2020: Animal Study

Minghong Deng ^1ACE , Chunwang Lin ^1AE* , Xianglin Zeng ^1C , Jianping Zhang ^1BD , Fang Wen ^1C , Ziguang Liu ^2B , Haiyan Wu ^3B , Xiaofeng Wu ^4B

DOI: 10.12659/MSM.922429

Med Sci Monit 2020; 26:e922429

Table 2 Determination of predictive abilities of p53, p521 and caspase-3 IRS values for CASMC apoptosis in KD mice.

Parameter	p53 IRS	p21 IRS	Caspase-3 IRS
AUC	0.889	0.997	0.976
95% CI	0.758–1.000	0.735–1.000	0.615–0.998
Sensitivity	0.917	1.000	0.917
Specificity	0.750	0.917	1.000
Positive likelihood ratio	11.6	12	11.8
Optimal cut-off, score	4.15	4.18	4.22