Involvement of p53, p21, and Caspase-3 in Apoptosis of Coronary Artery Smooth Muscle Cells in a Kawasaki Vasculitis Mouse Model

Minghong Deng; Chunwang Lin; Xianglin Zeng; Jianping Zhang; Fang Wen; Ziguang Liu; Haiyan Wu; Xiaofeng Wu

doi:10.12659/MSM.922429

21 August 2020 : Animal Research

Involvement of p53, p21, and Caspase-3 in Apoptosis of Coronary Artery Smooth Muscle Cells in a Kawasaki Vasculitis Mouse Model

Minghong Deng^1ACE, Chunwang Lin^1AE*, Xianglin Zeng^1C, Jianping Zhang^1BD, Fang Wen^1C, Ziguang Liu^2B, Haiyan Wu^3B, Xiaofeng Wu^4B

DOI: 10.12659/MSM.922429

Med Sci Monit 2020; 26:e922429

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Table 2 Determination of predictive abilities of p53, p521 and caspase-3 IRS values for CASMC apoptosis in KD mice.

Parameter	p53 IRS	p21 IRS	Caspase-3 IRS
AUC	0.889	0.997	0.976
95% CI	0.758–1.000	0.735–1.000	0.615–0.998
Sensitivity	0.917	1.000	0.917
Specificity	0.750	0.917	1.000
Positive likelihood ratio	11.6	12	11.8
Optimal cut-off, score	4.15	4.18	4.22

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Involvement of p53, p21, and Caspase-3 in Apoptosis of Coronary Artery Smooth Muscle Cells in a Kawasaki Vasculitis Mouse Model

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