21 June 2020>: Database Analysis
Development and Validation of Prognostic Nomograms for Patients with Duodenal Neuroendocrine Neoplasms
Shenghong Sun BDEF* , Wei Wang ACDFG** , Chiyi He ABG*DOI: 10.12659/MSM.922613
Med Sci Monit 2020; 26:e922613
Table 1 Clinical features and demographics of patients with D-NENs.
Characteristics | Overall survival | Cancer-specific survival | |||||
---|---|---|---|---|---|---|---|
N (%) | Patients | N (%) | Patients | ||||
Training | Validation | Training | Validation | ||||
Total | 965 | 677 | 288 | 845 | 593 | 252 | |
Age | 517 (53.6) | 364 (53.8) | 153 (53.1) | 484 (57.3) | 329 (55.5) | 155 (61.5) | |
≥65 | 488 (46.4) | 313 (46.2) | 135 (46.9) | 361 (42.7) | 246 (44.5) | 97 (38.5) | |
Race | White | 649 (67.3) | 454 (67.1) | 195 (67.7) | 576 (68.2) | 398 (67.1) | 178 (70.6) |
Black | 248 (25.7) | 168 (24.8) | 80 (27.8) | 208 (24.6) | 153 (25.8) | 55 (21.8) | |
Other | 68 (7.0) | 55 (8.1) | 13 (4.5) | 61 (7.2) | 42 (7.1) | 19 (7.5) | |
Gender | Female | 484 (50.2) | 336 (49.6) | 148 (51.4) | 421 (49.8) | 305 (51.4) | 116 (46.0) |
Male | 481 (49.8) | 341 (50.4) | 140 (48.6) | 424 (50.2) | 288 (48.6) | 136 (54.0) | |
Marital status | Yes | 531 (55.0) | 371 (54.8) | 160 (55.6) | 477 (56.4) | 327 (55.1) | 150 (59.5) |
No | 383 (39.7) | 265 (39.1) | 118 (41.0) | 325 (38.5) | 232 (39.1) | 93 (36.9) | |
Unknown | 51 (5.3) | 41 (6.1) | 10 (3.4) | 43 (5.1) | 34 (5.7) | 9 (3.6) | |
Year of diagnosis | 1988–2009 | 219 (22.7) | 153 (22.6) | 66 (22.9) | 159 (18.8) | 111 (18.7) | 48 (19.0) |
2010–2015 | 746 (77.3) | 524 (77.4) | 222 (77.1) | 686 (81.2) | 482 (81.3) | 204 (81.0) | |
Tumor grade | 1 | 801 (83.0) | 556 (82.1) | 245 (85.1) | 697 (82.5) | 488 (82.3) | 209 (82.9) |
2 | 136 (14.1) | 97 (14.3) | 39 (13.5) | 122 (14.4) | 86 (14.5) | 36 (14.3) | |
3/4 | 28 (2.9) | 24 (3.5) | 4 (1.4) | 26 (3.1) | 19 (3.2) | 7 (2.8) | |
Tumor size | 419 (43.4) | 310 (45.8) | 109 (37.8) | 365 (43.2) | 267 (45.0) | 98 (38.9) | |
1–2 cm | 380 (39.4) | 253 (37.4) | 127 (44.1) | 333 (39.4) | 233 (39.3) | 100 (39.7) | |
>2 cm | 166 (17.2) | 114 (16.8) | 52 (18.1) | 147 (17.4) | 93 (15.7) | 54 (21.4) | |
T stage | T1 | 555 (57.5) | 399 (58.9) | 156 (54.2) | 483 (57.2) | 349 (58.8) | 134 (53.2) |
T2 | 298 (30.9) | 202 (29.8) | 96 (33.3) | 260 (30.8) | 170 (28.7) | 90 (35.7) | |
T3 | 72 (7.5) | 46 (6.8) | 26 (9.0) | 62 (7.3) | 45 (7.6) | 17 (6.7) | |
T4 | 40 (4.1) | 30 (4.4) | 10 (3.5) | 40 (4.7) | 29 (4.9) | 11 (4.4) | |
N stage | N0 | 808 (83.7) | 564 (83.3) | 244 (84.7) | 703 (83.2) | 492 (83.0) | 211 (83.7) |
N1 | 157 (16.3) | 113 (16.7) | 44 (15.3) | 142 (16.8) | 101 (17.0) | 41 (16.3) | |
M stage | M0 | 919 (95.2) | 647 (95.6) | 272 (94.4) | 802 (94.9) | 567 (95.6) | 235 (93.3) |
M1 | 46 (4.8) | 30 (4.4) | 16 (5.6) | 43 (5.1) | 26 (4.4) | 17 (6.7) | |
Stage | I | 528 (54.7) | 380 (56.1) | 148 (51.4) | 458 (54.2) | 326 (55.0) | 132 (52.4) |
II | 247 (25.6) | 159 (23.4) | 88 (30.6) | 213 (25.2) | 148 (25.0) | 65 (25.8) | |
III | 143 (14.8) | 107 (15.8) | 36 (12.5) | 130 (15.4) | 92 (15.5) | 38 (15.1) | |
IV | 47 (4.9) | 31 (4.5) | 16 (5.5) | 44 (5.2) | 27 (4.5) | 17 (6.7) | |
Surgery | Yes | 818 (84.8) | 580 (85.7) | 238 (82.6) | 728 (86.2) | 513 (86.5) | 215 (85.3) |
No | 147 (15.2) | 97 (14.3) | 50 (17.4) | 117 (13.8) | 80 (13.5) | 37 (14.7) | |
D-NENs – primary duodenal neuroendocrine neoplasms; Race: Other – American Indian & AK Native & Asian & Pacific Islander; Marital status: Unmarried – Single & Separated & Divorced & Widowed & Unmarried or Domestic Partner. |