Development and Validation of Prognostic Nomograms for Patients with Duodenal Neuroendocrine Neoplasms

21 June 2020 : Database Analysis

Shenghong Sun^1BDEF, Wei Wang^1ACDFG*, Chiyi He^1ABG

DOI: 10.12659/MSM.922613

Med Sci Monit 2020; 26:e922613

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Table 3 Univariate and multivariate analyses of CSS in patients with D-NENs.

Characteristics		Cancer-specific survival
		Univariate analysis			Multivariate analysis
		HR	95% CI	P	HR	95% CI	P
Age	<65	Ref			Ref
Age	≥65	2.851	1.459–5.571		3.613	1.697–7.690
Race	White	Ref			Ref
	Black	0.723	0.331–1.578	0.415	0.535	0.214–1.336	0.181
	Other	0.328	0.045–2.408	0.273	0.347	0.043–2.772	0.318
Gender	Female	Ref			Ref
Gender	Male	0.812	0.431–1.529	0.519	0.903	0.431–1.892	0.786
Marital status	Married	Ref			Ref
	Unmarried	1.852	0.973–3.523	0.060	1.794	0.848–3.793	0.126
	Unknown	0.697	0.093–5.245	0.726	0.598	0.075–4.748	0.627
Year of diagnosis	1988–2009	Ref			Ref
Year of diagnosis	2010–2015	0.414	0.209–0.822		0.323	0.149–0.702
Tumor grade	1	Ref			Ref
	2	1.166	0.440–3.089	0.758	1.161	0.417–3.237	0.775
	3/4	17.507	8.625–35.537		9.342	3.539–24.659
Tumor size	<1 cm	Ref			Ref
	1–2 cm	1.883	0.740–4.788	0.184	1.586	0.508–4.945	0.427
	>2 cm	7.948	3.357–18.815		3.308	0.861–12.703	0.081
T stage	T1	Ref			Ref
	T2	1.428	0.574–3.553	0.444	0.705	0.227–2.188	0.545
	T3	5.400	2.169–13.446		2.149	0.559–8.260	0.266
	T4	12.925	5.675–29.436		3.446	0.946–12.555	0.061
N stage	N0	Ref			Ref
N stage	N1	2.946	1.543–5.625		0.600	0.216–1.665	0.327
M stage	M0	Ref			Ref
M stage	M1	4.376	1.915–10.000		3.586	1.299–9.899
Surgery	Yes	Ref			Ref
Surgery	No/Unknown	2.735	1.328–5.636		3.094	1.277–7.497
D-NENs – primary duodenal neuroendocrine neoplasms; Race: Other – American Indian & AK Native & Asian & Pacific Islander; Marital status: Unmarried – Single & Separated & Divorced & Widowed & Unmarried or Domestic Partner.

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