Retrospective Analysis of Clinical Outcomes in Patients with Immunoglobulin A Nephropathy and Persistent Hematuria Following Renin-Angiotensin System Blockade

Jingjing Chen; Shao Liu; Hui Xu; Wei Wang; Yanyun Xie; Wenbin Tang; Qiongjing Yuan; Li Zheng; Lizhen Lin; Shuangshuang Fu; Jinmei Shen

doi:10.12659/MSM.922839

21 August 2020 : Clinical Research

Retrospective Analysis of Clinical Outcomes in Patients with Immunoglobulin A Nephropathy and Persistent Hematuria Following Renin-Angiotensin System Blockade

Jingjing Chen^12ACE, Shao Liu^1ADE, Hui Xu^23AF*, Wei Wang^3BC, Yanyun Xie^3B, Wenbin Tang^3B, Qiongjing Yuan^3B, Li Zheng^4D, Lizhen Lin^35F, Shuangshuang Fu^6F, Jinmei Shen^7C

DOI: 10.12659/MSM.922839

Med Sci Monit 2020; 26:e922839

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Table 3 Multivariate Cox regression analysis for the effect of RASB on the primary outcome of IgAN patients only with persistent hematuria initially.

Models	All (n=110)	P	Patients without hypertension (n=99)	P
Models	HR (95% CI)	P	HR (95% CI)	P
Model 1^*
With RASB	0.34 (0.16–0.75)	0.01	0.23 (0.09–0.59)	0.002
Without RASB	Reference	–	–	–
Model 2^**
With RASB	0.28 (0.12–0.65)	0.003	0.21 (0.08–0.55)	0.002
Without RASB	Reference	–	–	–
Model 3^***
With RASB	0.22 (0.09–0.53)	0.001	0.17 (0.06–0.46)	0.001
Without RASB	Reference	–	–	–
^* Adjusted by gender and age; ^ adjusted by gender, age, hypertension, hyperuricemia, initial eGFR, duration from initial diagnosis to start of therapy and initial hematuria; ^* Model 2+Oxford classification factors (M, E, S, T and C). RASB – renin–angiotensin system blockers; HR – hazard ratio; CI – confidence interval.

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Retrospective Analysis of Clinical Outcomes in Patients with Immunoglobulin A Nephropathy and Persistent Hematuria Following Renin-Angiotensin System Blockade

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