Myoglobin Mediates Autophagy of NRK-52E in Rat Renal Tubular Epithelial Cells Via the Pink1/Parkin Signaling Pathway

Zhiguo Chen; Jinxiang Wang; Jiao He; Haojun Fan; Shike Hou; Qi Lv

doi:10.12659/MSM.923045

22 July 2020 : Laboratory Research

Myoglobin Mediates Autophagy of NRK-52E in Rat Renal Tubular Epithelial Cells Via the Pink1/Parkin Signaling Pathway

Zhiguo Chen^123ABCD, Jinxiang Wang^1ABCD, Jiao He^1BCD, Haojun Fan^24ADG, Shike Hou^24ABCDEFG*, Qi Lv^24BCD

DOI: 10.12659/MSM.923045

Med Sci Monit 2020; 26:e923045

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Table 2 PCR array results.

Symbol	50 um/0 um	Symbol	100 um/0 um	Symbol	150 um/0 um
Tnf	4.24	Pink1	5.43	Ifng	6.70
Ifng	4.10	Ins2	4.43	Tnf	4.47
Ins2	3.54	Ifng	3.62	Irgm	4.17
Pink1	2.43	Tnf	2.66	Pink1	2.94
Ctss	2.29	Irgm	2.58	Casp8	2.54
Park7	2.05	Park7	2.35	Fas	2.39
Tgfb1	2.00	Fas	2.02	Mapt	2.32
Cdkn2a	1.96	Sqstm1	1.95	Ctss	2.21
Atg16l2	1.90	Atg16l2	1.91	Dram2	2.18
Fas	1.83	Casp8	1.85	Esr1	2.15
Pim2	1.79	Cdkn2a	1.75	Park7	2.05
Bad	1.69	Eif2ak3	1.73	Cln3	1.94
Irgm	1.57	Esr1	1.72	Atg16l1	1.89
Actb	1.53	Beclin1	1.71	Sqstm1	1.83
Sqstm1	1.50	Bad	1.66	Pik3r4	1.81
Casp8	1.43	Dram2	1.62	Rb1cc1	1.68
Rplp1	1.40	Hdac6	1.54	Cdkn2a	1.66
Cln3	1.38	Mapt	1.47	Pik3c3	1.57
Map1lc3a	1.38	Rps6kb1	1.47	Atg4c	1.56
Nfkb1	1.35	Cdig2	1.45	Atg16l2	1.56
Akt1	1.35	Map1lc3a	1.44	Casp3	1.54
Bid	1.32	Atg3	1.44	Pik3cg	1.53
Tp53	1.31	Tp53	1.43	B2m	1.51
Atg4b	1.31	Bid	1.33	Map1lc3a	1.50
Bak1	1.29	Atg16l1	1.32	Hsp90aa1	1.50
Atg16l1	1.28	Rplp1	1.31	Cdig2	1.47
Dapk1	1.24	Rb1cc1	1.30	Rps6kb1	1.45
Atg9a	1.21	Nfkb1	1.29	Actb	1.44
Cdig2	1.19	Mapk8	1.28	Bak1	1.40
Esr1	1.15	B2m	1.27	Beclin1	1.39
Rab24	1.15	Atg4b	1.26	Gabarap	1.37
Hgs	1.13	Actb	1.25	Atg4b	1.37
Beclin1	1.12	Gabarapl2	1.23	Gabarapl2	1.37
Gaa	1.12	Tgfb1	1.23	Psen1	1.34
Igf1	1.09	Cln3	1.22	Rab24	1.34
Rgs19	1.06	Rab24	1.21	Bid	1.31
RGD1359310	1.04	Pik3c3	1.21	Atg3	1.31
Mtor	1.03	Tm9sf1	1.18	Rgs19	1.30
Psen1	1.02	Pim2	1.16	Bad	1.28
Mapt	1.01	Htt	1.16	Pten	1.27
Gabarapl2	1.01	Ctss	1.16	Bcl2	1.27
Atg3	1.00	RGD1359310	1.15	Tgm2	1.26
Fadd	−1.01	Atg12	1.15	Nfkb1	1.26
Gabarap	−1.02	Hdac1	1.12	Lamp1	1.25
B2m	−1.04	Psen1	1.12	Pim2	1.23
Ctsd	−1.04	Pik3r4	1.12	Hgs	1.23
Atg5	−1.06	Gaa	1.10	Atg9a	1.22
Tm9sf1	−1.08	Atg9a	1.10	Mtor	1.20
Hdac6	−1.08	Casp3	1.09	Ctsb	1.18
Lamp1	−1.09	Map1lc3b	1.09	Map1lc3b	1.18
Htt	−1.11	Lamp1	1.07	Htt	1.17
Map1lc3b	−1.14	Gabarap	1.06	Fadd	1.16
Ctsb	−1.15	Prkaa1	1.00	Mapk14	1.14
Wipi1	−1.15	Mtor	−1.00	Gaa	1.13
Ulk1	−1.18	Atg5	−1.01	Ins2	1.06
Mapk14	−1.18	Fadd	−1.02	Tgfb1	1.06
Arsa	−1.18	Atg4c	−1.02	Eif2ak3	1.05
Hdac1	−1.19	Hgs	−1.03	RGD1359310	1.05
Pik3r4	−1.20	Hsp90aa1	−1.04	Hdac6	1.05
Pik3c3	−1.20	Bcl2l1	−1.05	Hprt1	1.04
App	−1.23	Hprt1	−1.08	Rplp1	1.04
Bax	−1.23	Rgs19	−1.09	Atg7	1.03
Eif2ak3	−1.25	Bak1	−1.09	Ctsd	−1.00
Bcl2l1	−1.29	Bcl2	−1.12	Tm9sf1	−1.01
Atg4c	−1.33	Ctsd	−1.12	Mapk8	−1.03
Cdkn1b	−1.37	Akt1	−1.12	Tp53	−1.03
Rps6kb1	−1.40	Pten	−1.13	Atg12	−1.05
Atg7	−1.40	Arsa	−1.16	Ulk1	−1.08
Ldha	−1.43	Mapk14	−1.17	Bcl2l1	−1.10
Casp3	−1.43	Bax	−1.17	Ambra1	−1.14
Hprt1	−1.44	Ctsb	−1.19	Atg5	−1.14
Ambra1	−1.48	Eif4g1	−1.22	Rb1	−1.18
Dram2	−1.48	Atg7	−1.23	Akt1	−1.22
Pten	−1.57	Wipi1	−1.26	Prkaa1	−1.25
Atg12	−1.57	Rb1	−1.30	Hdac1	−1.35
Tnfsf10	−1.60	Cdkn1b	−1.30	Eif4g1	−1.40
Hsp90aa1	−1.67	App	−1.35	Wipi1	−1.46
Mapk8	−1.67	Ulk1	−1.42	Cdkn1b	−1.56
Rb1	−1.70	Ambra1	−1.43	Park2	−1.64
Prkaa1	−1.80	Park2	−1.56	App	−1.71
Eif4g1	−2.08	Tgm2	−1.68	Bax	−1.81
Bnip3	−2.14	Bnip3	−1.76	Bnip3	−1.83
Cxcr4	−2.15	Ldha	−1.92	Tnfsf10	−1.85
Bcl2	−2.34	Cxcr4	−2.31	Arsa	−1.91
Snca	−2.46	Dapk1	−2.44	Cxcr4	−2.36
Pik3cg	−2.54	Igf1	−2.60	Ldha	−2.37
Park2	−2.82	Tnfsf10	−2.67	Igf1	−3.35
Rb1cc1	−3.68	Pik3cg	−2.73	Snca	−7.85
Tgm2	−4.58	Snca	−3.17	Dapk1	−19.76

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Myoglobin Mediates Autophagy of NRK-52E in Rat Renal Tubular Epithelial Cells Via the Pink1/Parkin Signaling Pathway

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