A Network Pharmacology Analysis of the Active Components of the Traditional Chinese Medicine Zuojinwan in Patients with Gastric Cancer

Zheyu Zhang; Bin Li; Jianhua Huang; Siqi Huang; Dan He; Weijun Peng; Sifang Zhang

doi:10.12659/MSM.923327

31 August 2020: Database Analysis

A Network Pharmacology Analysis of the Active Components of the Traditional Chinese Medicine Zuojinwan in Patients with Gastric Cancer

Zheyu Zhang ^1AE* , Bin Li ^2B* , Jianhua Huang ^3C , Siqi Huang ^1B , Dan He ^3D , Weijun Peng ^1FG* , Sifang Zhang ^1G*

DOI: 10.12659/MSM.923327

Med Sci Monit 2020; 26:e923327

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Table 1 A list of the active compounds in Zuojinwan for network analysis.

MOL ID	Compound name	Molecular formula	OB	DL
MOL001454	Berberine	C20H18NO4+	36.86	0.78
MOL013352	Obacunone	C26H30O7	43.29	0.77
MOL000098	Quercetin	C15H10O7	46.43	0.28
MOL002662	Rutaecarpine	C18H13N3O	40.3	0.6
MOL000354	Isorhamnetin	C16H12O7	49.6	0.31
MOL000358	Beta-sitosterol	C29H50O	36.91	0.75
MOL000359	Sitosterol	C29H50O	36.91	0.75
MOL003942	Rutaevine	C26H30O9	66.05	0.58
MOL003943	Rutalinidine	C15H17NO4	40.89	0.22
MOL003947	1-methyl-2-[(Z)-pentadec-10-enyl]-4-quinolone	C25H37NO	48.45	0.46
MOL003950	1-methyl-2-[(Z)-undec-6-enyl]-4-quinolone	C21H29NO	48.48	0.27
MOL003956	Dihydrorutaecarpine	C18H15N3O	42.27	0.6
MOL003957	1-methyl-2-pentadecyl-4-quinolone	C25H39NO	44.52	0.46
MOL003958	Evodiamine	C19H17N3O	86.02	0.64
MOL003960	1-(5,7,8-trimethoxy-2,2-dimethylchromen-6-yl)ethanone	C16H20O5	30.39	0.18
MOL003963	Hydroxyevodiamine	C19H17N3O2	72.11	0.71
MOL003964	1-methyl-2-undecyl-4-quinolone	C21H31NO	47.59	0.27
MOL003972	1-methyl-2-nonyl-4-quinolone	C19H27NO	48.42	0.2
MOL003974	Evocarpine	C23H33NO	48.66	0.36
MOL003975	Icosa-11,14,17-trienoic acid methyl ester	C21H36O2	44.81	0.23
MOL003988	2-Hydroxy-3-formyl-7-methoxycarbazole	C14H11NO3	83.08	0.18
MOL003994	24-methyl-31-norlanost-9(11)-enol	C30H52O	38	0.75
MOL004002	5alpha-O-(3′-methylamino-3′-phenylpropionyl)nicotaxine	C40H48N2O10	30.86	0.49
MOL004004	6-OH-Luteolin	C15H10O7	46.93	0.28
MOL004014	Evodiamide	C19H21N3O	73.77	0.28
MOL004017	Fordimine	C16H20N2O	55.11	0.26
MOL004018	Goshuyuamide I	C19H19N3O	83.19	0.39
MOL004019	Goshuyuamide II	C19H17N3O2	69.11	0.43
MOL004020	Gossypetin	C15H10O8	35	0.31
MOL004021	Gravacridoneshlirine	C19H18ClNO4	63.73	0.54
MOL004025	N-(2-methylaminobenzoyl)tryptamine	C18H19N3O	56.96	0.26
MOL004345	1-methyl-2-nonyl-4(1h)-quinolone	C39H67NO	31.54	0.5
MOL002419	Higenamine	C16H17NO3	82.54	0.21
MOL002894	Berberrubine	C19H16ClNO4	35.74	0.73
MOL002897	Epiberberine	C20H18NO4+	43.09	0.78
MOL002903	(R)-Canadine	C20H21NO4	55.37	0.77
MOL002904	Berlambine	C20H17NO5	36.68	0.82
MOL002907	Corchoroside A_qt	C23H32O6	104.95	0.78
MOL000622	Magnograndiolide	C15H22O4	63.71	0.19
MOL000762	Palmidin A	C30H22O8	35.36	0.65
MOL000785	Palmatine	C21H22NO4+	64.6	0.65
MOL001458	Coptisine	C19H14NO4	30.67	0.86
MOL002668	Worenine	C20H16NO4+	45.83	0.87
MOL008647	Moupinamide	C18H19NO4	86.71	0.26
MOL002714	Baicalein	C15H10O5	33.52	0.21
MOL002776	Baicalin	C21H18O11	40.12	0.75
MOL000173	Wogonin	C16H12O5	30.68	0.23
OB – oral bioavailability; DL – drug-likeness.

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A Network Pharmacology Analysis of the Active Components of the Traditional Chinese Medicine Zuojinwan in Patients with Gastric Cancer

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