A Network Pharmacology Analysis of the Active Components of the Traditional Chinese Medicine Zuojinwan in Patients with Gastric Cancer

31 August 2020: Database Analysis

Zheyu Zhang ^1AE* , Bin Li ^2B* , Jianhua Huang ^3C , Siqi Huang ^1B , Dan He ^3D , Weijun Peng ^1FG* , Sifang Zhang ^1G*

DOI: 10.12659/MSM.923327

Med Sci Monit 2020; 26:e923327

Table 4 Virtual docking of 4 representative ingredients from Zuojinwan for gastric cancer targets.

Compound	Binding energy/(kcal·mol−1)
Compound	MMP9	MMP3	MMP1
Original ligands	−7.9091	−11.8849	−14.5777
Berberine	−5.8617	−5.6970	−5.7199
Isorhamnetin	−5.8996	−7.3793	−7.1915
Quercetin	−6.1569	−7.2459	−7.1467
Wogonin	−6.4024	−5.7839	−5.9911
(R)-Canadine	−5.1318	−6.2006	−5.6461
Baicalein	−4.9929	−5.7758	−6.3437
Baicalin	−7.5559	−7.0784	−7.4166
Berlambine	−5.5981	−7.0967	−5.5062
Evodiamine	−5.1372	−6.1891	−5.3646
MMP – matrix metalloproteinases.