Efficacy of Primary Tumor Resection in Metastatic Colorectal Cancer

29 August 2020 : Database Analysis

Yong Huang^1BCEF, Kuanxue Ge^2BCD, Guangshun Fu^1F, Junfeng Chu^3AB, Wei Wei^1AE*

DOI: 10.12659/MSM.923501

Med Sci Monit 2020; 26:e923501

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Table 3 The results of multivariate Cox regression analyses of OS in the whole cohort.

Variable	Reference	Characteristic	Cancer-specific survival
Variable	Reference	Characteristic	HR (95% CI)	SE	P value
Age at diagnosis	<65	≥65	1.397 (1.370–1.425)	0.010	<0.001
Tumor location	Colon	Rectum	0.811 (0.793–0.829)	0.011	<0.001
Surgery of the primary tumor	No	Yes	0.430 (0.417–0.443)	0.015	<0.001
T stage	T1	T2	0.733 (0.681–0.790)	0.038	<0.001
		T3	0.889 (0.854–0.925)	0.020	<0.001
		T4	1.122 (1.079–1.168)	0.020	<0.001
		Unknown	1.078 (1.039–1.119)	0.019	<0.001
N stage	N0	N1	1.188 (1.158–1.220)	0.013	<0.001
		N2	1.594 (1.548–1.641)	0.015	<0.001
		Unknown	1.142 (1.107–1.178)	0.016	<0.001
Race	White	Black	1.108 (1.079–1.138)	0.013	<0.001
		Other	0.914 (0.883–0.946)	0.018	<0.001
Gender	Male	Female	0.985 (0.967–1.004)	0.010	0.124
Year of diagnosis	2004	2005	1.024 (0.982–1.067)	0.021	0.262
		2006	0.989 (0.949–1.030)	0.021	0.595
		2007	1.000 (0.959–1.042)	0.021	0.995
		2008	0.987 (0.947–1.029)	0.021	0.535
		2009	0.924 (0.887–0.963)	0.021	<0.001
		2010	0.932 (0.894–0.971)	0.021	0.001
		2011	0.977 (0.938–1.019)	0.021	0.282
		2012	0.911 (0.873–0.950)	0.021	<0.001
		2013	0.904 (0.866–0.943)	0.022	<0.001
Chemotherapy	No	Yes	0.459 (0.450–0.468)	0.010	<0.001

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