16 December 2020 : Animal Research
Network Pharmacology Study of the Hepatoprotective Effects of Quercetin-Containing Traditional Chinese Medicine, Anoectochilus roxburghii, and Validation of Quercetin as an Anti-Liver Injury Agent in a Mouse Model of Liver Injury
Wei Lin12ABCDEF, Yuhan Wu3ABCDF, Jingjing Wang3BCDF, Han Lin2BCDF, Xiuming Xu1ADF, Guanrong He4A, Bizhu He23AG*, Xiaokai Ma12AFDOI: 10.12659/MSM.923533
Med Sci Monit 2020; 26:e923533
Table 1 The major bio-active compounds in Anoectochilus roxburghii (AR).
| Mol ID | Chemical compound | MW | Hdon | Hacc | OB (%) | Caco-2 | DL |
|---|---|---|---|---|---|---|---|
| MOL000098 | Quercetin | 302.25 | 5 | 7 | 46.43 | 0.05 | 0.28 |
| MOL005921 | Quercetin-7-O-β-D-glucoside | 300.28 | 5 | 6 | 49.57 | 0.13 | 0.27 |
| MOL000354 | Isorhamnetin | 316.28 | 4 | 7 | 49.6 | 0.31 | 0.31 |
| MOL000351 | Rhamnazin | 330.31 | 3 | 7 | 47.14 | 0.53 | 0.34 |
| MOL000493 | Campesterol | 400.76 | 1 | 1 | 37.58 | 1.31 | 0.71 |
| MOL001979 | Lanosterol | 426.8 | 1 | 1 | 42.12 | 1.52 | 0.75 |
| MOL000449 | Stigmasterol | 412.77 | 1 | 1 | 43.83 | 1.44 | 0.76 |
| MW – molecular weight; Hdon – hydrogen-bond donors; Hacc – hydrogen-bond acceptors; OB – oral bioavailability; Caco-2 – Caco-2 cell permeability, DL – drug-likeness. | |||||||