16 December 2020 : Animal Research
Network Pharmacology Study of the Hepatoprotective Effects of Quercetin-Containing Traditional Chinese Medicine, Anoectochilus roxburghii, and Validation of Quercetin as an Anti-Liver Injury Agent in a Mouse Model of Liver Injury
Wei Lin12ABCDEF, Yuhan Wu3ABCDF, Jingjing Wang3BCDF, Han Lin2BCDF, Xiuming Xu1ADF, Guanrong He4A, Bizhu He23AG*, Xiaokai Ma12AFDOI: 10.12659/MSM.923533
Med Sci Monit 2020; 26:e923533
Table 2 Seventeen hub targets of Anoectochilus roxburghii (AR) against liver injury identified by topological analysis.
| Uniprot ID | Gene symbol | Protein name | Degree |
|---|---|---|---|
| P05231 | IL6 | Interleukin-6 | 38 |
| P05412 | JUN | Transcription factor AP-1 | 37 |
| P01375 | TNFA | Tumor necrosis factor | 37 |
| P04637 | TP53 | Cellular tumor antigen p53 | 37 |
| P15692 | VEGFA | Vascular endothelial growth factor A | 35 |
| P00533 | EGFR | Epidermal growth factor receptor | 29 |
| P01584 | IL1B | Interleukin-1 beta | 29 |
| P01106 | MYC | Myc proto-oncogene protein | 28 |
| MMP9 | MMP9 | Matrix metalloproteinase-9 | 26 |
| P01133 | EGF | Pro-epidermal growth factor | 26 |
| P24385 | CCND1 | G1/S-specific cyclin-D1 | 26 |
| P10145 | CXCL8 | Interleukin-8 | 26 |
| P35354 | PTGS2 | Prostaglandin G/H synthase 2 | 25 |
| Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 24 |
| P01100 | FOS | Proto-oncogene c-Fos | 24 |
| P22301 | IL10 | Interleukin-10 | 24 |
| Q04206 | RELA | Transcription factor p65 (NF-κB p65) | 24 |