Catechol-O-Methyltransferase Gene Polymorphisms and the Risk of Chemotherapy-Induced Prospective Memory Impairment in Breast Cancer Patients with Varying Tumor Hormonal Receptor Expression

28 September 2020 : Clinical Research

Wen Li^1ABCE, Jingjing Zhao^2B, Ke Ding^2B, Herta H. Chao^3E, Chiang-Shan R. Li^4BC, Huaidong Cheng^2AG*, Li Shen^5AG

DOI: 10.12659/MSM.923567

Med Sci Monit 2020; 26:e923567

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Table 2 Neuropsychological performance before and after chemotherapy.

Task	Mean±SD
Task	Before chemotherapy (n=232)	After chemotherapy (n=232)
MMSE	27.27±1.57	26.65±1.64^*
DST	6.19±0.73	5.95±0.97^**
VFT	11.48±1.52	9.96±2.13^**
EBPM	2.72±1.01	2.00±1.19^**
TBPM	4.98 ± 0.97	4.75 ±0.91^*
^* ^** MMSE – Mini-Mental State Examination; DST – digit span test; VFT – verbal fluency test; EBPM – event-based prospective memory task; TBPM – time-based prospective memory task.

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