28 September 2020>: Clinical Research
Catechol-O-Methyltransferase Gene Polymorphisms and the Risk of Chemotherapy-Induced Prospective Memory Impairment in Breast Cancer Patients with Varying Tumor Hormonal Receptor Expression
Wen Li 1ABCE , Jingjing Zhao 2B , Ke Ding 2B , Herta H. Chao 3E , Chiang-Shan R. Li 4BC , Huaidong Cheng 2AG* , Li Shen 5AG*DOI: 10.12659/MSM.923567
Med Sci Monit 2020; 26:e923567
Table 4 Sequencing of the 3 genes in the 2 groups.
SNP | COMT | APOE | BDNF | |||
---|---|---|---|---|---|---|
rs4680 | rs165599 | rs737865 | rs429358 | rs7412 | rs6265 | |
CHR | 22 | 22 | 22 | 19 | 19 | 11 |
Allele position | 19951271 | 19956781 | 19930121 | 45411941 | 45412079 | 27679916 |
Ref allele | G | G | A | T | C | C |
Alt allele | A | A | G | C | T | T |
MAF | 0.256 | 0.479 | 0.315 | 0.080 | 0.088 | 0.492 |
P for HWE | 0.480 | 0.183 | 0.469 | 0.586 | 0.472 | 0.977 |
* | 0.586 | 0.091 | 0.264 | 0.492 | 0.860 | 0.663 |
SNP – single-nucleotide polymorphism; CHR – chromosome; Ref allele – alleles in the on the reference sequence; Alt allele – the other (alternative) allele on the locus of the Ref allele; MAF – minor allele frequency (data from 1000 Genomes); HWE – Hardy-Weinberg equilibrium; P for HWE – -value for HWE in 2 groups; – -value for allele frequency differences between the 2 groups. |