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28 September 2020: Clinical Research

Catechol-O-Methyltransferase Gene Polymorphisms and the Risk of Chemotherapy-Induced Prospective Memory Impairment in Breast Cancer Patients with Varying Tumor Hormonal Receptor Expression

Wen Li 1ABCE , Jingjing Zhao 2B , Ke Ding 2B , Herta H. Chao 3E , Chiang-Shan R. Li 4BC , Huaidong Cheng 2AG* , Li Shen 5AG*

DOI: 10.12659/MSM.923567

Med Sci Monit 2020; 26:e923567

Table 4 Sequencing of the 3 genes in the 2 groups.

Allele position199512711995678119930121454119414541207927679916
Ref alleleGGATCC
Alt alleleAAGCTT
P for HWE0.4800.1830.4690.5860.4720.977
SNP – single-nucleotide polymorphism; CHR – chromosome; Ref allele – alleles in the on the reference sequence; Alt allele – the other (alternative) allele on the locus of the Ref allele; MAF – minor allele frequency (data from 1000 Genomes); HWE – Hardy-Weinberg equilibrium; P for HWE – -value for HWE in 2 groups; – -value for allele frequency differences between the 2 groups.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750