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28 September 2020: Clinical Research

Catechol-O-Methyltransferase Gene Polymorphisms and the Risk of Chemotherapy-Induced Prospective Memory Impairment in Breast Cancer Patients with Varying Tumor Hormonal Receptor Expression

Wen Li 1ABCE , Jingjing Zhao 2B , Ke Ding 2B , Herta H. Chao 3E , Chiang-Shan R. Li 4BC , Huaidong Cheng 2AG* , Li Shen 5AG*

DOI: 10.12659/MSM.923567

Med Sci Monit 2020; 26:e923567

Table 5 Genotype frequencies of SNPs of the 3 genes between the 2 groups.

SNPModelGenotypeER−/PR−ER+/PR+P* (χ2)Logistic regression
OR (95% CI)P**
rs4680CodominantG/G7064
G/A33490.1200.868 (0.521–1.448)0.588
A/A1061.842 (0.937–3.62)0.076
DominantG/G70640.2081.403 (0.833–2.362)0.204
G/A+A/A4355
RecessiveG/G+G/A1031130.2530.633 (0.232–1.723)0.370
A/A106
Additive1.14 (0.757–1.716)0.531
rs6265CodominantT/T2330
T/C59570.6641.10 (0.767–1.596)0.586
C/C31320.834 (0.499–1.396)0.490
DominantT/T23300.3791.008 (0.567–1.792)0.978
T/C+C/C9089
RecessiveT/T+T/C82870.9261.29 (0.697–2.389)0.418
C/C3132
Additive1.097 (0.762–1.578)0.618
rs165599CodominantG/G3522
G/A56700.0871.423 (0.967–2.093)0.073
A/A22271.418 (0.842–2.387)0.190
DominantG/G35220.0272.019 (1.097–3.717)0.024
G/A+A/A7897
RecessiveG/G+G/A91920.5481.245 (0.664–2.335)0.494
A/A2227
Additive1.44 (0.979–2.118)0.064
rs737865CodominantA/A5860
A/G48430.0981.641 (0.997–2.703)0.052
G/G6160.519 (0.272–0.991)0.047
DominantA/A58600.8361.056 (0.632–1.767)0.834
A/G+G/G5459
RecessiveA/A+A/G1061030.0362.888 (1.096–7.612)0.032
G/G616
Additive1.259 (0.852–1.862)0.248
rs429358CodominantT/T93101
T/C20170.4923.819e+004 (0-inf)0.999
C/C012.01e–005 (0-inf)0.999
DominantT/T931010.5970.813 (0.405–1.63)0.559
T/C+C/C2018
RecessiveT/T+T/C1131180.3291.521e+009 (0-inf)0.999
C/C01
Additive0.873 (0.448–1.703)0.691
rs7412CodominantC/C9398
C/T19210.5482.411e–005 (0-inf)0.999
T/T104.511e+004 (0-inf)0.999
DominantC/C93980.9921.033 (0.530–2.016)0.923
C/T+T/T2021
RecessiveC/C+C/T1121190.3045.73e–010 (0-inf)0.999
T/T10
Additive0.975 (0.521–1.856)0.938
* χ – test of P values for SNP polymorphism distribution differences between 2 groups;
** P-value for logistic regression analysis; OR – odds ratio (OR); 95% CI – 95% confidence interval; Models – various genetic models that were defined as 1 (MM+Mm) versus 0 (mm) for dominant; 1 (mm) versus 0 (MM+Mm) for recessive; and 0 (mm) versus 1 (Mm) versus 2 (MM) for additive and codominant (M and m represent major and minor alleles, respectively).

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750