28 September 2020 : Clinical Research
Catechol-O-Methyltransferase Gene Polymorphisms and the Risk of Chemotherapy-Induced Prospective Memory Impairment in Breast Cancer Patients with Varying Tumor Hormonal Receptor Expression
Wen Li1ABCE, Jingjing Zhao2B, Ke Ding2B, Herta H. Chao3E, Chiang-Shan R. Li4BC, Huaidong Cheng2AG*, Li Shen5AGDOI: 10.12659/MSM.923567
Med Sci Monit 2020; 26:e923567
Table 6 Correlation analysis between COMT (rs737865) and CICI.
| Model | Genotype | B (95% CI) | P-value | |
|---|---|---|---|---|
| MMSE | Dominant | A/A | 1.078 (0.92~1.264) | 0.351 |
| G/A+G/G | ||||
| Recessive | A/A+G/A | 0.971 (0.746~1.256) | 0.830 | |
| G/G | ||||
| HOM | A/A | 1.007 (0.767~1.319) | 0.958 | |
| HET | G/A | 1.090 (0.920~1.292) | 0.318 | |
| DST | Dominant | A/A | 0.956 (0.73~1.25) | 0.746 |
| G/A+G/G | ||||
| Recessive | A/A+G/A | 0.841 (0.532~1.329) | 0.458 | |
| G/G | ||||
| HOM | – | 0.843 (0.525~−1.353) | 0.478 | |
| HET | G/A | 1.004 (0.754~−1.336) | 0.979 | |
| VFT | Dominant | A/A | 0.949 (0.84~1.072) | 0.400 |
| G/A+G/G | ||||
| Recessive | A/A+G/A | 1.209 (0.977~1.496) | 0.081 | |
| G/G | ||||
| HOM | A/A | 1.168 (0.93~1.466) | 0.181 | |
| HET | G/A | 0.910 (0.799~1.036) | 0.153 | |
| EBPM | Dominant | A/A | 1.117 (0.898~1.388) | 0.321 |
| G/A+G/G | ||||
| Recessive | A/A+G/A | 1.499 (1.017~2.211) | 0.041 | |
| G/G | ||||
| HOM | A/A | 1.536 (1.02~2.313) | 0.040 | |
| HET | G/A | 1.039 (0.826~1.306) | 0.745 | |
| TBPM | Dominant | A/A | 0.941 (0.707~1.253) | 0.941 |
| G/A+G/G | ||||
| Recessive | A/A+G/A | 1.021 (0.627~1.663) | 0.934 | |
| G/G | ||||
| HOM | A/A | 1.002 (0.589~1.705) | 0.994 | |
| HET | G/A | 0.959 (0.710~1.295) | 0.783 | |
| HOM – homozygote; HET – heterozygote; beta – regression coefficient; 95% CI – 95% confidence interval | ||||