Kupffer Cells Regulate Natural Killer Cells Via the NK group 2, Member D (NKG2D)/Retinoic Acid Early Inducible-1 (RAE-1) Interaction and Cytokines in a Primary Biliary Cholangitis Mouse Model

Hai-Yan Fu; Wei-Min Bao; Cai-Xia Yang; Wei-Ju Lai; Jia-Min Xu; Hai-Yan Yu; Yi-Na Yang; Xu Tan; Ajay Kumar Gupta; Ying-Mei Tang

doi:10.12659/MSM.923726

29 June 2020 : Animal Research

Kupffer Cells Regulate Natural Killer Cells Via the NK group 2, Member D (NKG2D)/Retinoic Acid Early Inducible-1 (RAE-1) Interaction and Cytokines in a Primary Biliary Cholangitis Mouse Model

Hai-Yan Fu^1EF, Wei-Min Bao^2C, Cai-Xia Yang^1D, Wei-Ju Lai^1D, Jia-Min Xu^1B, Hai-Yan Yu^1B, Yi-Na Yang^1B, Xu Tan^1B, Ajay Kumar Gupta^1F, Ying-Mei Tang^1AG*

DOI: 10.12659/MSM.923726

Med Sci Monit 2020; 26:e923726

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Supplementary Table 2 Expression of RAE-1 and F4/80 after stimulation of Kupffer with different concentrations of LPS.

	Group	KCs	KCs+LPS1	KCs+LPS10	F
RAE-1	PBC	26.89±2.26	42.05±6.03	51.23±4.17	61.6088
	CON	17.67±1.77	19.09±1.68	27.65±3.40	39.9400
		9.0845	10.3745	12.3957

F4/80	PBC	42.68±4.26	63.52±4.85	65.49±6.05	48.9818
	CON	34.88±4.81	46.18±2.41	50.99±7.68	18.6682
		3.43360	9.05594	4.19487
		0.002		0.0004
RAE-1 – retinoic acid early inducible-1; LPS – lipopolysaccharide; PBC – primary biliary cholangitis; CON – control.

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Kupffer Cells Regulate Natural Killer Cells Via the NK group 2, Member D (NKG2D)/Retinoic Acid Early Inducible-1 (RAE-1) Interaction and Cytokines in a Primary Biliary Cholangitis Mouse Model

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