Kupffer Cells Regulate Natural Killer Cells Via the NK group 2, Member D (NKG2D)/Retinoic Acid Early Inducible-1 (RAE-1) Interaction and Cytokines in a Primary Biliary Cholangitis Mouse Model

Hai-Yan Fu; Wei-Min Bao; Cai-Xia Yang; Wei-Ju Lai; Jia-Min Xu; Hai-Yan Yu; Yi-Na Yang; Xu Tan; Ajay Kumar Gupta; Ying-Mei Tang

doi:10.12659/MSM.923726

29 June 2020 : Animal Research

Kupffer Cells Regulate Natural Killer Cells Via the NK group 2, Member D (NKG2D)/Retinoic Acid Early Inducible-1 (RAE-1) Interaction and Cytokines in a Primary Biliary Cholangitis Mouse Model

Hai-Yan Fu^1EF, Wei-Min Bao^2C, Cai-Xia Yang^1D, Wei-Ju Lai^1D, Jia-Min Xu^1B, Hai-Yan Yu^1B, Yi-Na Yang^1B, Xu Tan^1B, Ajay Kumar Gupta^1F, Ying-Mei Tang^1AG*

DOI: 10.12659/MSM.923726

Med Sci Monit 2020; 26:e923726

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Supplementary Table 4 Expression of NKG2D and RAE-1 and F4/80 in NK cells co-cultured with 10 ug/mL LPS-stimulated Kupffer cells.

	PBC	CON	t	P
NKG2D	41.65±4.81	12.00±1.00	19.0850
RAE-1	9.02±0.74	8.20±0.60	2.7219	0.0140
F4/80	12.47±1.73	9.23±1.32	4.7084	0.0002
NKG2D – natural killer group 2, member D; RAE-1 – retinoic acid early inducible-1; NK – natural killer; LPS – lipopolysaccharide; PBC – primary biliary cholangitis; CON – control.

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Kupffer Cells Regulate Natural Killer Cells Via the NK group 2, Member D (NKG2D)/Retinoic Acid Early Inducible-1 (RAE-1) Interaction and Cytokines in a Primary Biliary Cholangitis Mouse Model

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