03 August 2020: Review Articles
Galectins for Diagnosis and Prognostic Assessment of Human Diseases: An Overview of Meta-Analyses
Yiting Liu 12ABCDEF* , Hao Meng 13ABCDEF* , Shixue Xu 1ABCDEF* , Xingshun Qi 1ABCDEF*DOI: 10.12659/MSM.923901
Med Sci Monit 2020; 26:e923901
Table 2 Evidence from meta-analyses regarding clinical use of galectins in cardiovascular diseases.
| First author | Journal (Year) | Regions | No. studies (Pts.) | Galectins studied | Diseases studied | Outcomes of interests | Effect sizes | Conclusions |
|---|---|---|---|---|---|---|---|---|
| Chen H | Heart Fail Rev (2019) | China Zhejiang | 18 (7057) | Circulating galectin-3 | Acute heart failure | All-cause mortality Cardiovascular mortality Heart failure re-hospitalization | Risk ratio | A significant association between higher serum galectin-3 and higher risks of all-cause mortality and cardiovascular mortality in acute heart failure patients No significant association between higher serum galectin-3 and heart failure rehospitalization |
| Huang Z | Herz (2018) | China Guangdong | 8 (6995) | Galectin-3 | Heart failure | Diagnosis | Area under the curve Diagnostic odds ratio Sensitivity Specificity | The diagnostic accuracy of galectin-3 for heart failure is relatively good |
| Imran T | Am J Cardiol (2017) | USA New Jersey | 18 (32350)* | Galectin-3 | Heart failure | All-cause mortality Cardiovascular mortality | Hazard ratio | Elevated plasma galectin-3 is significantly associated with a higher risk of all-cause mortality and cardiovascular mortality of heart failure patients |
| Chen Y | Biomark Med (2016) | China Taiwan | 22 (6995) | Galectin-3 | Acute and chronic heart failure | All-cause mortality | Area under the curve Diagnostic odds ratio Sensitivity Specificity | Elevated levels of galectin-3 can significantly predict all-cause mortality of heart failure patients |
| Chen A | Int J Cardiol (2015) | China Shanghai | 11 (8419) | Galectin-3 | Heart failure | All-cause mortality Cardiovascular mortality | Hazard ratio | A significant association between increased levels of galectin-3 and increased risk of all-cause mortality and cardiovascular mortality |
| Gong M | J Clin Lab Anal (2020) | China Tianjin | 28 (10830) | Galectin-3 | Atrial fibrillation Persistent atrial fibrillation | Presence Risk of development Risk of recurrence | Mean difference Odds ratio Hazard ratio | Galectin-3 is significantly associated with atrial fibrillation and persistent atrial fibrillation Galectin-3 can predict both atrial fibrillation development and recurrence after treatment |
| Pranata R | Indian Pacing Electrophysiol J (2020) | Indonesia Tangerang | 7 (597) | Galectin-3 | Atrial fibrillation post-ablation | Recurrence post-ablation | Mean difference Hazard ratio | Serum galectin-3 is associated with an increased risk of atrial fibrillation recurrence post-ablation |
| Zhang G | Cardiovasc Ther (2019) | China Beijing | 7 (645) | Circulating galectin-3 | Atrial fibrillation patients undergoing catheter ablation | Risk of recurrence | Mean difference Risk ratio | A significant association between higher preprocedural galectin-3 level and increased risk of atrial fibrillation recurrence in patients undergoing catheter ablation |
| Li W | Atherosclerosis (2010) | China Beijing | 7 (21097) | Galectin-2-encoding gene (LGALS2) -C3279T gene polymorphism | Coronary artery disease | Risk of development | Odds ratio | No significant association between LGALS2 -C3279T gene polymorphism and coronary artery disease |
| Misra S | Meta Gene (2016) | India New Delhi | 2 (2025) | Galectin-2-encoding gene (LGALS2) -C3279T gene polymorphism | Ischemic stroke | Risk of development | Odds ratio | No significant association between LGALS2 -C3279T gene polymorphism and ischemic stroke |
| * Studies included heart failure patients and general population. | ||||||||