19 July 2020 : Database Analysis
Systematic Profiling of Alternative Splicing for Sarcoma Patients Reveals Novel Prognostic Biomarkers Associated with Tumor Microenvironment and Immune Cells
Chuan Hu1ABCEF*, Yuanhe Wang1ABC, Chuan Liu2DEF, Rui Shen1DE, Bo Chen3F, Kang Sun1B, Huili Rao4C, Lin Ye3E, Jianjun Ye3C, Shaoqi Tian1ABCDEFDOI: 10.12659/MSM.924126
Med Sci Monit 2020; 26:e924126
Table 1 Multivariate COX analysis of overall survival-related AS events.
| Symbol | AS type | HR | Lower.95 | Upper.95 | P value |
|---|---|---|---|---|---|
| CLTC | ES | 1.07E-07 | 5.61E-12 | 0.002039 | 0.001413 |
| PSMG1 | ES | 0.001137 | 2.26E-05 | 0.057229 | 0.000697 |
| INPP5B | AA | 81.747094 | 16.300191 | 409.969893 | 8.67E-08 |
| CTNND1 | ES | 0.000118 | 2.85E-07 | 0.048717 | 0.003252 |
| TAF1A | AT | 10073.277430 | 92.247074 | 1099990.640000 | 0.000118 |
| TMEM161B | AT | 0.006279 | 0.000411 | 0.095853 | 0.000266 |
| NMRAL1 | RI | 5.839665 | 1.239303 | 27.516829 | 0.025665 |
| SIRT3 | ES | 2.74E-09 | 1.15E-18 | 6.539018 | 0.073531 |
| HS1BP3 | ES | 8.42E-08 | 2.03E-11 | 0.000349 | 0.000126 |
| CCDC91 | ES | 4.748142 | 1.195326 | 18.860833 | 0.026864 |
| C19orf60 | ES | 0.001407 | 1.08E-06 | 1.825446 | 0.072588 |
| AS – alternative splicing; ES – exon skip; RI – retained intron; AT – alternate terminator; AA – alternate acceptor. | |||||