Fiber Type-Specific Morphological and Cellular Changes of Paraspinal Muscles in Patients with Severe Adolescent Idiopathic Scoliosis

Xiexiang Shao; Jian Chen; Jingfan Yang; Wenyuan Sui; Yaolong Deng; Zifang Huang; Ping Hu; Junlin Yang

doi:10.12659/MSM.924415

30 July 2020: Clinical Research

Fiber Type-Specific Morphological and Cellular Changes of Paraspinal Muscles in Patients with Severe Adolescent Idiopathic Scoliosis

Xiexiang Shao ^1ABCEF* , Jian Chen ^1ABCF* , Jingfan Yang ^1ADFG* , Wenyuan Sui ^1BDFG , Yaolong Deng ^1BCEF , Zifang Huang ^2BCE , Ping Hu ^3ACEG* , Junlin Yang ^1ABCDEG*

DOI: 10.12659/MSM.924415

Med Sci Monit 2020; 26:e924415

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Table 4 Correlation analysis between clinical parameters and the bilateral differences of fiber type specific morphological/cellular characteristics.

	Age at initiation		Cobb angle		AVT		CB
	r	P value	r	P value	r	P value	r	P value
Difference of type I numerical proportion	−0.120	0.711	−0.002	0.996	−0.494	0.103	−0.167	0.603
Difference of type I area proportion	−0.198	0.537	−0.061	0.850	−0.182	0.571	0.091	0.779
Ratio of CSA
Type I	0.004	0.991		^*	0.497	0.100	0.040	0.901
Type II	−0.172	0.593		^*	0.322	0.307	−0.269	0.398
Total	0.007	0.982		^*	0.438	0.155	−0.180	0.576
Difference of myonuclei density
Type I	−0.071	0.826	0.302	0.341		^*	−0.150	0.641
Type II	0.108	0.737	−0.175	0.587	−0.133	0.680	−0.329	0.297
Total	0.093	0.773	0.326	0.301	0.571	0.053	−0.349	0.266
Difference of total SC density
Type I	−0.228	0.476	0.351	0.263		^*	0.465	0.127
Type II	0.150	0.643	0.266	0.403		^*	0.088	0.787
Total	−0.019	0.954	0.346	0.271	0.539	0.070	0.328	0.297
Difference of activated SC density
Type I	−0.116	0.720	0.495	0.102		^*	0.053	0.870
Type II	0.225	0.482	0.269	0.399	−0.025	0.940	−0.523	0.081
Total	−0.064	0.844	0.575	0.050	0.392	0.207	−0.427	0.166
AVT – apical vertebrae translation; CB – coronal balance; CSA – cross sectional area; SC – satellite cell. ^* Significant if value

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Fiber Type-Specific Morphological and Cellular Changes of Paraspinal Muscles in Patients with Severe Adolescent Idiopathic Scoliosis

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