22 August 2020 : Clinical Research
Dynamin 2 Is Correlated with Recurrence and Poor Prognosis of Papillary Thyroid Cancer
Ning Ren1BCF, Zhenmin Tian2CE, Hongmei Sun3BD, Xiaofei Lu4ABCDEF*DOI: 10.12659/MSM.924590
Med Sci Monit 2020; 26:e924590
Table 3 Prognostic value of dynamin 2 (DNM2) and other clinicopathological factors were evaluated by univariate and multivariate analyses.
| Variables | 5-year OS | P* | HR | 95% CI | P** |
|---|---|---|---|---|---|
| Sex | |||||
| Male | 89.0 | 0.380 | |||
| Female | 86.6 | ||||
| Age | |||||
| <45 | 88.3 | 0.438 | |||
| ≥45 | 93.7 | ||||
| Tumor size (cm) | |||||
| ≤2 | 91.4 | 0.905 | |||
| >2 | 92.3 | ||||
| Tumor number | |||||
| Single | 92.7 | 0.681 | |||
| Multiple | 92.3 | ||||
| Differentiation | |||||
| Good | 92.4 | 0.105 | 1 | ||
| Moderate | 92.6 | 1.43 | 0.32–6.34 | 0.636 | |
| Site | |||||
| Left or right | 92.6 | 0.674 | |||
| Left+right | 91.7 | ||||
| T stage | |||||
| I+II | 95.0 | 0.037 | 1 | ||
| III+IV | 72.9 | 1.31 | 0.30–5.67 | 0.720 | |
| N stage | |||||
| N0 | 90.7 | 0.009 | 1 | ||
| N1 | 85.7 | 5.87 | 1.26–27.2 | 0.024 | |
| TNM stage | |||||
| I+II | 93.7 | 0.060 | |||
| III+IV | 88.4 | ||||
| DNM2 | |||||
| Low | 96.7 | 0.004 | 1 | ||
| High | 78.5 | 4.82 | 1.46–15.92 | 0.010 | |
| * Calculated by the log-rank test in univariate analysis; ** calculated by the Cox-regression hazard model in multivariate analysis. OS – overall survival; HR – hazard ratio; CI – confidence interval; TNM – tumor-node-metastasis. | |||||