11 August 2020: Database Analysis
Early Death Incidence and Prediction in Stage IV Breast Cancer
Yumei Zhao 1BE , Guijun Xu 2B , Xinpeng Guo 1F , Wenjuan Ma 1CG , Yao Xu 2C , Karl Peltzer 3F , Vladimir P. Chekhonin 4E , Vladimir P. Baklaushev 5D , Nan Hu 6DG , Xin Wang 7DG , Zheng Liu 28A* , Chao Zhang 2AG*DOI: 10.12659/MSM.924858
Med Sci Monit 2020; 26:e924858
Table 2 Univariate logistic regression for analyzing the risk factors for early death in patients with IV breast cancer.
| Subject characteristics | Total early death | Cancer specific early death | Non-cancer specific early death | |||
|---|---|---|---|---|---|---|
| OR (95% CI) | P value | OR (95% CI) | P value | OR (95% CI) | P value | |
| Age | ||||||
| Ref | 1.0 | Ref | 1.0 | Ref | 1.0 | |
| 50–59 | 1.57 (1.40–1.74) | 1.47 (1.31–1.66) | 1.63 (1.31–2.03) | |||
| 60–69 | 1.99 (1.80–2.22) | 1.73 (1.54–1.94) | 2.30 (1.87–2.83) | |||
| 70–79 | 2.92 (2.62–3.26) | 2.26 (2.00–2.54) | 3.49 (2.83–4.30) | |||
| ≥80 | 5.11 (4.55–5.74) | 3.18 (2.81–3.60) | 5.83 (4.74–7.17) | |||
| Marital status | ||||||
| Married | Ref | 1.0 | Ref | 1.0 | Ref | 1.0 |
| Unmarried | 1.80 (1.69–1.92) | 1.67 (1.55–1.79) | 1.60 (1.43–1.78) | |||
| Race | ||||||
| White | Ref | 1.0 | Ref | 1.0 | Ref | 1.0 |
| Black | 1.36 (1.26–1.48) | 1.29 (1.18–1.41) | 1.29 (1.13–1.47) | |||
| Others | 0.80 (0.71–0.91) | 0.001 | 0.83 (0.72–0.95) | 0.007 | 0.83 (0.67–1.03) | 0.089 |
| Insurance | ||||||
| Insured | Ref | 1.0 | Ref | 1.0 | Ref | 1.0 |
| Uninsured | 1.50 (1.29–1.74) | 1.81 (1.55–2.11) | 0.65 (0.47–0.88) | 0.006 | ||
| Subtypes | ||||||
| Luminal A | Ref | 1.0 | Ref | 1.0 | Ref | 1.0 |
| Luminal B | 0.88 (0.79–0.98) | 0.017 | 0.99 (0.88–1.11) | 0.864 | 0.67 (0.55–0.82) | |
| HER2 enriched | 1.51 (1.33–1.71) | 1.57 (1.37–1.80) | 1.14 (0.92–1.42) | 0.234 | ||
| Triple negative | 4.06 (3.68–4.48) | 3.49 (3.15–3.87) | 2.26 (1.95–2.62) | |||
| Grade | ||||||
| Grade I | Ref | 1.0 | Ref | 1.0 | Ref | 1.0 |
| Grade II | 1.50 (1.28–1.76) | 1.59 (1.32–1.92) | 1.18 (0.91–1.53) | 0.214 | ||
| Grade III | 2.43 (2.08–2.84) | 2.67 (2.22–3.21) | 1.40 (1.08–1.80) | 0.010 | ||
| Grade IV | 3.71 (2.44–5.65) | 4.34 (2.79–6.75) | 1.34 (0.63–2.86) | 0.454 | ||
| Tumor site | ||||||
| UOQ | Ref | 1.0 | Ref | 1.0 | Ref | 1.0 |
| LOQ | 0.85 (0.72–1.00) | 0.051 | 0.84 (0.70–1.02) | 0.072 | 0.92 (0.70–1.22) | 0.564 |
| LIQ | 0.87 (0.72–1.06) | 0.173 | 0.81 (0.64–1.01) | 0.058 | 1.09 (0.80–1.49) | 0.577 |
| UIQ | 0.92 (0.79–1.07) | 0.272 | 0.91 (0.77–1.08) | 0.271 | 0.98 (0.76–1.26) | 0.852 |
| CEN | 0.97 (0.84–1.13) | 0.712 | 0.99 (0.83–1.17) | 0.870 | 0.95 (0.73–1.23) | 0.705 |
| Others | 1.06 (0.96–1.17) | 0.287 | 1.04 (0.93–1.16) | 0.477 | 1.06 (0.90–1.26) | 0.472 |
| Laterality | ||||||
| Left-sided | Ref | 1.0 | Ref | 1.0 | Ref | 1.0 |
| Right-sided | 0.98 (0.92–1.05) | 0.534 | 0.97 (0.91–1.04) | 0.419 | 1.01 (0.91–1.13) | 0.848 |
| One side, NOS | 1.45 (0.94–2.24) | 0.090 | 1.63 (1.04–2.56) | 0.033 | 0.83 (0.36–1.90) | 0.655 |
| Paired sides | 1.73 (1.51–1.98) | 1.50 (1.30–1.73) | 1.67 (1.36–2.04) | |||
| Tumor size | ||||||
| 0–2 cm | Ref | 1.0 | Ref | 1.0 | Ref | 1.0 |
| 2–5 cm | 1.09 (0.98–1.21) | 0.100 | 1.29 (1.15–1.45) | 0.77 (0.66–0.90) | 0.001 | |
| >5 cm | 1.33 (1.20–1.48) | 1.80 (1.59–2.03) | 0.60 (0.51–0.71) | |||
| N stage | ||||||
| N0 | Ref | 1.0 | Ref | 1.0 | Ref | 1.0 |
| N1 | 0.73 (0.67–0.79) | 0.92 (0.83–1.01) | 0.065 | 0.51 (0.44–0.59) | ||
| N2 | 0.63 (0.55–0.72) | 0.76 (0.66–0.89) | 0.52 (0.41–0.65) | |||
| N3 | 1.00 (0.92–1.09) | 0.976 | 1.21 (1.10–1.33) | 0.67 (0.58–0.77) | ||
| Bone Met | ||||||
| No | Ref | 1.0 | Ref | 1.0 | Ref | 1.0 |
| Yes | 0.72 (0.67–0.77) | 0.81 (0.76–0.87) | 0.65 (0.59–0.73) | |||
| Brain Met | ||||||
| No | Ref | 1.0 | Ref | 1.0 | Ref | 1.0 |
| Yes | 3.00 (2.69–3.35) | 2.65 (2.37–2.96) | 1.77 (1.51–2.08) | |||
| Liver Met | ||||||
| No | Ref | 1.0 | Ref | 1.0 | Ref | 1.0 |
| Yes | 2.06 (1.93–2.21) | 2.15 (2.00–2.32) | 1.21 (1.08–1.36) | 0.001 | ||
| Lung Met | ||||||
| No | Ref | 1.0 | Ref | 1.0 | Ref | 1.0 |
| Yes | 1.75 (1.64–1.87) | 1.80 (1.68–1.93) | 1.20 (1.08–1.33) | 0.001 | ||
| Surgery | ||||||
| No surgery | Ref | 1.0 | Ref | 1.0 | Ref | 1.0 |
| PM | 0.41 (0.36–0.47) | 0.38 (0.33–0.45) | 0.69 (0.56–0.85) | |||
| TM | 0.33 (0.28–0.38) | 0.31 (0.26–0.38) | 0.57 (0.44–0.73) | |||
| RM | 0.29 (0.26–0.33) | 0.32 (0.28–0.37) | 0.38 (0.31–0.48) | |||
| Others | 0.38 (0.18–0.79) | 0.009 | 0.30 (0.12–0.76) | 0.011 | 0.85 (0.31–2.37) | 0.756 |
| SEER – Surveillance, Epidemiology, and End Result; OR – odds ratio; CI – confidence interval; Ref – reference; NA – not applicable; UOQ – upper outer quadrant; LOQ – lower outer quadrant; LIQ – lower inner quadrant; UIQ – upper inner quadrant; CEN – central portion; NOS – not otherwise specified; PM – partial mastectomy; TM – total mastectomy; RM – radical mastectomy. | ||||||