Early Death Incidence and Prediction in Stage IV Breast Cancer

Yumei Zhao; Guijun Xu; Xinpeng Guo; Wenjuan Ma; Yao Xu; Karl Peltzer; Vladimir P. Chekhonin; Vladimir P. Baklaushev; Nan Hu; Xin Wang; Zheng Liu; Chao Zhang

doi:10.12659/MSM.924858

11 August 2020 : Database Analysis

Early Death Incidence and Prediction in Stage IV Breast Cancer

Yumei Zhao^1BE, Guijun Xu^2B, Xinpeng Guo^1F, Wenjuan Ma^1CG, Yao Xu^2C, Karl Peltzer^3F, Vladimir P. Chekhonin^4E, Vladimir P. Baklaushev^5D, Nan Hu^6DG, Xin Wang^7DG, Zheng Liu^28A, Chao Zhang^2AG*

DOI: 10.12659/MSM.924858

Med Sci Monit 2020; 26:e924858

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Table 2 Univariate logistic regression for analyzing the risk factors for early death in patients with IV breast cancer.

Subject characteristics	Total early death		Cancer specific early death		Non-cancer specific early death
Subject characteristics	OR (95% CI)	P value	OR (95% CI)	P value	OR (95% CI)	P value
Age
<50	Ref	1.0	Ref	1.0	Ref	1.0
50–59	1.57 (1.40–1.74)	<0.001	1.47 (1.31–1.66)	<0.001	1.63 (1.31–2.03)	<0.001
60–69	1.99 (1.80–2.22)	<0.001	1.73 (1.54–1.94)	<0.001	2.30 (1.87–2.83)	<0.001
70–79	2.92 (2.62–3.26)	<0.001	2.26 (2.00–2.54)	<0.001	3.49 (2.83–4.30)	<0.001
≥80	5.11 (4.55–5.74)	<0.001	3.18 (2.81–3.60)	<0.001	5.83 (4.74–7.17)	<0.001
Marital status
Married	Ref	1.0	Ref	1.0	Ref	1.0
Unmarried	1.80 (1.69–1.92)	<0.001	1.67 (1.55–1.79)	<0.001	1.60 (1.43–1.78)	<0.001
Race
White	Ref	1.0	Ref	1.0	Ref	1.0
Black	1.36 (1.26–1.48)	<0.001	1.29 (1.18–1.41)	<0.001	1.29 (1.13–1.47)	<0.001
Others	0.80 (0.71–0.91)	0.001	0.83 (0.72–0.95)	0.007	0.83 (0.67–1.03)	0.089
Insurance
Insured	Ref	1.0	Ref	1.0	Ref	1.0
Uninsured	1.50 (1.29–1.74)	<0.001	1.81 (1.55–2.11)	<0.001	0.65 (0.47–0.88)	0.006
Subtypes
Luminal A	Ref	1.0	Ref	1.0	Ref	1.0
Luminal B	0.88 (0.79–0.98)	0.017	0.99 (0.88–1.11)	0.864	0.67 (0.55–0.82)	<0.001
HER2 enriched	1.51 (1.33–1.71)	<0.001	1.57 (1.37–1.80)	<0.001	1.14 (0.92–1.42)	0.234
Triple negative	4.06 (3.68–4.48)	<0.001	3.49 (3.15–3.87)	<0.001	2.26 (1.95–2.62)	<0.001
Grade
Grade I	Ref	1.0	Ref	1.0	Ref	1.0
Grade II	1.50 (1.28–1.76)	<0.001	1.59 (1.32–1.92)	<0.001	1.18 (0.91–1.53)	0.214
Grade III	2.43 (2.08–2.84)	<0.001	2.67 (2.22–3.21)	<0.001	1.40 (1.08–1.80)	0.010
Grade IV	3.71 (2.44–5.65)	<0.001	4.34 (2.79–6.75)	<0.001	1.34 (0.63–2.86)	0.454
Tumor site
UOQ	Ref	1.0	Ref	1.0	Ref	1.0
LOQ	0.85 (0.72–1.00)	0.051	0.84 (0.70–1.02)	0.072	0.92 (0.70–1.22)	0.564
LIQ	0.87 (0.72–1.06)	0.173	0.81 (0.64–1.01)	0.058	1.09 (0.80–1.49)	0.577
UIQ	0.92 (0.79–1.07)	0.272	0.91 (0.77–1.08)	0.271	0.98 (0.76–1.26)	0.852
CEN	0.97 (0.84–1.13)	0.712	0.99 (0.83–1.17)	0.870	0.95 (0.73–1.23)	0.705
Others	1.06 (0.96–1.17)	0.287	1.04 (0.93–1.16)	0.477	1.06 (0.90–1.26)	0.472
Laterality
Left-sided	Ref	1.0	Ref	1.0	Ref	1.0
Right-sided	0.98 (0.92–1.05)	0.534	0.97 (0.91–1.04)	0.419	1.01 (0.91–1.13)	0.848
One side, NOS	1.45 (0.94–2.24)	0.090	1.63 (1.04–2.56)	0.033	0.83 (0.36–1.90)	0.655
Paired sides	1.73 (1.51–1.98)	<0.001	1.50 (1.30–1.73)	<0.001	1.67 (1.36–2.04)	<0.001
Tumor size
0–2 cm	Ref	1.0	Ref	1.0	Ref	1.0
2–5 cm	1.09 (0.98–1.21)	0.100	1.29 (1.15–1.45)	<0.001	0.77 (0.66–0.90)	0.001
>5 cm	1.33 (1.20–1.48)	<0.001	1.80 (1.59–2.03)	<0.001	0.60 (0.51–0.71)	<0.001
N stage
N0	Ref	1.0	Ref	1.0	Ref	1.0
N1	0.73 (0.67–0.79)	<0.001	0.92 (0.83–1.01)	0.065	0.51 (0.44–0.59)	<0.001
N2	0.63 (0.55–0.72)	<0.001	0.76 (0.66–0.89)	<0.001	0.52 (0.41–0.65)	<0.001
N3	1.00 (0.92–1.09)	0.976	1.21 (1.10–1.33)	<0.001	0.67 (0.58–0.77)	<0.001
Bone Met
No	Ref	1.0	Ref	1.0	Ref	1.0
Yes	0.72 (0.67–0.77)	<0.001	0.81 (0.76–0.87)	<0.001	0.65 (0.59–0.73)	<0.001
Brain Met
No	Ref	1.0	Ref	1.0	Ref	1.0
Yes	3.00 (2.69–3.35)	<0.001	2.65 (2.37–2.96)	<0.001	1.77 (1.51–2.08)	<0.001
Liver Met
No	Ref	1.0	Ref	1.0	Ref	1.0
Yes	2.06 (1.93–2.21)	<0.001	2.15 (2.00–2.32)	<0.001	1.21 (1.08–1.36)	0.001
Lung Met
No	Ref	1.0	Ref	1.0	Ref	1.0
Yes	1.75 (1.64–1.87)	<0.001	1.80 (1.68–1.93)	<0.001	1.20 (1.08–1.33)	0.001
Surgery
No surgery	Ref	1.0	Ref	1.0	Ref	1.0
PM	0.41 (0.36–0.47)	<0.001	0.38 (0.33–0.45)	<0.001	0.69 (0.56–0.85)	<0.001
TM	0.33 (0.28–0.38)	<0.001	0.31 (0.26–0.38)	<0.001	0.57 (0.44–0.73)	<0.001
RM	0.29 (0.26–0.33)	<0.001	0.32 (0.28–0.37)	<0.001	0.38 (0.31–0.48)	<0.001
Others	0.38 (0.18–0.79)	0.009	0.30 (0.12–0.76)	0.011	0.85 (0.31–2.37)	0.756
SEER – Surveillance, Epidemiology, and End Result; OR – odds ratio; CI – confidence interval; Ref – reference; NA – not applicable; UOQ – upper outer quadrant; LOQ – lower outer quadrant; LIQ – lower inner quadrant; UIQ – upper inner quadrant; CEN – central portion; NOS – not otherwise specified; PM – partial mastectomy; TM – total mastectomy; RM – radical mastectomy.

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Early Death Incidence and Prediction in Stage IV Breast Cancer

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