Early Death Incidence and Prediction in Stage IV Breast Cancer

Yumei Zhao; Guijun Xu; Xinpeng Guo; Wenjuan Ma; Yao Xu; Karl Peltzer; Vladimir P. Chekhonin; Vladimir P. Baklaushev; Nan Hu; Xin Wang; Zheng Liu; Chao Zhang

doi:10.12659/MSM.924858

11 August 2020 : Database Analysis

Early Death Incidence and Prediction in Stage IV Breast Cancer

Yumei Zhao^1BE, Guijun Xu^2B, Xinpeng Guo^1F, Wenjuan Ma^1CG, Yao Xu^2C, Karl Peltzer^3F, Vladimir P. Chekhonin^4E, Vladimir P. Baklaushev^5D, Nan Hu^6DG, Xin Wang^7DG, Zheng Liu^28A, Chao Zhang^2AG*

DOI: 10.12659/MSM.924858

Med Sci Monit 2020; 26:e924858

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Table 3 Multivariate logistic regression for analyzing the risk factors for early death in patients with IV breast cancer.

Subject characteristics	Total early death		Cancer specific early death		Non-cancer specific early death
Subject characteristics	OR (95% CI)	P Value	OR (95% CI)	P Value	OR (95% CI)	P Value
Age
<50	Ref	1.0	Ref	1.0	Ref	1.0
50–59	1.59 (1.35–1.89)	<0.001	1.51 (1.26–1.80)	<0.001	1.52 (1.09–2.13)	0.014
60–69	2.22 (1.88–2.63)	<0.001	1.84 (1.54–2.20)	<0.001	2.5 (1.83–3.44)	<0.001
70–79	3.48 (2.90–4.17)	<0.001	2.41 (1.98–2.93)	<0.001	4.25 (3.08–5.86)	<0.001
≥80	7.04 (5.78–8.57)	<0.001	3.95 (3.21–4.87)	<0.001	7.37 (5.31–10.22)	<0.001
Marital status
Married	Ref	1.0	Ref	1.0	Ref	1.0
Unmarried	1.40 (1.26–1.56)	<0.001	1.39 (1.23–1.56)	<0.001	1.19 (1–1.42)	0.052
Race
White	Ref	1.0	Ref	1.0	Ref	1.0
Black	1.36 (1.19–1.57)	<0.001	1.28 (1.10–1.48)	0.001	1.34 (1.08–1.67)	0.009
Others	0.91 (0.74–1.12)	0.381	0.94 (0.75–1.17)	0.570	0.88 (0.61–1.27)	0.505
Insurance
Insured	Ref	1.0	Ref	1.0	Ref	1.0
Uninsured	1.31 (1.00–1.72)	0.048	1.52 (1.15–2.00)	0.003	0.61 (0.33–1.11)	0.103
Subtypes
Luminal A	Ref	1.0	Ref	1.0	Ref	1.0
Luminal B	0.78 (0.67–0.91)	0.002	0.81 (0.68–0.96)	0.014	0.83 (0.63–1.08)	0.164
HER2 enriched	1.17 (0.97–1.42)	0.107	1.11 (0.90–1.36)	0.318	1.23 (0.9–1.69)	0.193
Triple Negative	3.76 (3.23–4.37)	<0.001	3.06 (2.62–3.57)	<0.001	2.09 (1.66–2.62)	<0.001
Grade
Grade I	Ref	1.0	Ref	1.0	Ref	1.0
Grade II	1.56 (1.25–1.95)	<0.001	1.59 (1.22–2.06)	0.001	1.27 (0.91–1.79)	0.165
Grade III	2.22 (1.76–2.79)	<0.001	2.29 (1.76–2.99)	<0.001	1.42 (1–2.02)	0.053
Grade IV	1.44 (0.70–2.93)	0.321	1.95 (0.94–4.07)	0.075	0.57 (0.13–2.49)	0.454
Laterality
Left-sided	Ref	1.0	Ref	1.0	Ref	1.0
Right-sided	0.99 (0.90–1.10)	0.888	1.00 (0.89–1.12)	0.998	0.98 (0.83–1.15)	0.768
One side, NOS	–	1.000	–	1.000	–	1.000
Paired sides	2.66 (0.72–9.79)	0.142	2.45 (0.67–8.94)	0.176	1.28 (0.15–10.76)	0.821
Tumor size
0–2 cm	Ref	1.0	Ref	1.0	Ref	1.0
2–5 cm	1.05 (0.91–1.22)	0.519	1.21 (1.02–1.43)	0.027	0.82 (0.66–1.02)	0.070
>5 cm	1.32 (1.13–1.54)	0.001	1.69 (1.42–2.01)	<0.001	0.67 (0.53–0.86)	0.001
N stage
N0	Ref	1.0	Ref	1.0	Ref	1.0
N1	0.77 (0.67–0.89)	<0.001	0.97 (0.84–1.13)	0.731	0.56 (0.45–0.69)	<0.001
N2	0.82 (0.67–1.01)	0.066	0.91 (0.72–1.14)	0.419	0.77 (0.56–1.06)	0.112
N3	0.94 (0.81–1.09)	0.395	1.03 (0.87–1.20)	0.769	0.84 (0.67–1.05)	0.117
Bone Met
No	Ref	1.0	Ref	1.0	Ref	1.0
Yes	1.11 (0.99–1.24)	0.088	1.15 (1.02–1.31)	0.027	0.91 (0.76–1.1)	0.325
Brain Met
No	Ref	1.0	Ref	1.0	Ref	1.0
Yes	3.67 (3.04–4.40)	<0.001	2.94 (2.44–3.54)	<0.001	2.03 (1.55–2.65)	<0.001
Liver Met
No	Ref	1.0	Ref	1.0	Ref	1.0
Yes	2.28 (2.03–2.56)	<0.001	2.2 (1.95–2.48)	<0.001	1.41 (1.17–1.7)	<0.001
Lung Met
No	Ref	1.0	Ref	1.0	Ref	1.0
Yes	1.30 (1.16–1.45)	<0.001	1.36 (1.21–1.53)	<0.001	0.96 (0.8–1.15)	0.675
Surgery
No surgery	Ref	1.0	Ref	1.0	Ref	1.0
PM	0.46 (0.38–0.56)	<0.001	0.44 (0.35–0.54)	<0.001	0.76 (0.57–1)	0.049
TM	0.42 (0.34–0.51)	<0.001	0.41 (0.32–0.52)	<0.001	0.71 (0.52–0.98)	0.036
RM	0.39 (0.33–0.46)	<0.001	0.41 (0.34–0.49)	<0.001	0.59 (0.45–0.77)	<0.001
Others	0.75 (0.29–1.94)	0.557	0.65 (0.22–1.93)	0.435	1.23 (0.28–5.34)	0.786
SEER – Surveillance, Epidemiology, and End Result; OR – odds ratio; CI – confidence interval; Ref – reference; NA – not applicable; UOQ – upper outer quadrant; LOQ – lower outer quadrant; LIQ – lower inner quadrant; UIQ – upper inner quadrant; CEN – central portion; NOS – not otherwise specified; PM – partial mastectomy; TM – total mastectomy; RM = radical mastectomy.

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Early Death Incidence and Prediction in Stage IV Breast Cancer

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