23 September 2020: Clinical Research
Gamma Knife Radiosurgery (GKRS) for Patients with Prolactinomas: Long-Term Results From a Single-Center Experience
Yanli Li 1AEG* , Minyi Huang 2BCD* , Shunyao Liang 2BC* , Chao Peng 3CDE , Xi Li 4BCD , Jiamin Zeng 5CD , Yong He 2BF , Wangen Li 1EF , Yinhui Deng 2ADG , Jinxiu Yu 2BCE*DOI: 10.12659/MSM.924884
Med Sci Monit 2020; 26:e924884
Table 2 Outcomes of 24 patients who underwent GKRS.
| Outcomes | No. (%) |
|---|---|
| Imaging outcome | |
| Tumor shrinkage | 23 (95.8) |
| Tumor stable | 1 (4.2) |
| Tumor progression | 0 |
| Endocrine outcomes | |
| Endocrine remission | 10 (41.7) |
| Endocrine control | 6 (25) |
| Persistent hyperprolactinaemia | 8 (33.3) |
| Resolved hypopituitarism after GKRS | |
| Gonadotrophin deficiency | 7 (29.2) |
| ACTH deficiency | 0 |
| TSH deficiency | 1 (4.2) |
| New-onset hypopituitarism | 4 (16.7) |
| Gonadotrophin deficiency | 3 (12.5) |
| ACTH deficiency | 0 |
| TSH deficiency | 1 (4.2) |
| Visual function | |
| Visual dysfunction improved* | 4 |
| Visual dysfunction worsen* | 0 |
| Cranial nerve dysfunction of after GKRS | 0 |
| GKRS – gamma knife radiosurgery; PRL – prolactin; ACTH – adrenocorticotropic hormone; TSH – thyroid-stimulating hormone; DAs – dopamine agonist. * Visual dysfunction including visual field defect or visual acuity decrease or both. | |