HMGA1 Promotes Hepatic Metastasis of Colorectal Cancer by Inducing Expression of Glucose Transporter 3 (GLUT3)

29 September 2020 : Clinical Research

Meijing Yang^1ABC, Yang Guo^1DE, Xiaoyun Liu^2E, Naiqing Liu^3ABCDEF*

DOI: 10.12659/MSM.924975

Med Sci Monit 2020; 26:e924975

Table 3 The prognostic value of HMGA1 and other factors.

Factors	Univariate		Multivariate
Factors	Medium OS time	P*	HR	95% CI	P**
Sex
Male	21.4	0.659
Female	28.2
Age
	18.4	0.043	1
≥60	27.5		0.42	0.22–0.83	0.012
Differentiation
Good	29.9	0.232
Moderate+poor	19.4
Lymph node invasion
No (N0)	30.2	0.449
Yes (N1/2)	20.2
Number of CRCLM
	29.7	0.026	1
≥3	21.8		3.10	0.53–18.23	0.212
CRCLM distribution
Unilobar	26.1	0.695
Bilobar	27.8
HMGA1
Low	34	0.014	1
High	17.7		2.37	1.26–4.44	0.007
GLUT3
Low	29.5	0.039	1
High	22.6		0.58	0.10–3.46	0.554
^* Log-rank test; ^** Cox-regression model.