29 September 2020 : Clinical Research
HMGA1 Promotes Hepatic Metastasis of Colorectal Cancer by Inducing Expression of Glucose Transporter 3 (GLUT3)
Meijing Yang1ABC, Yang Guo1DE, Xiaoyun Liu2E, Naiqing Liu3ABCDEF*DOI: 10.12659/MSM.924975
Med Sci Monit 2020; 26:e924975
Table 3 The prognostic value of HMGA1 and other factors.
| Factors | Univariate | Multivariate | |||
|---|---|---|---|---|---|
| Medium OS time | P* | HR | 95% CI | P** | |
| Sex | |||||
| Male | 21.4 | 0.659 | |||
| Female | 28.2 | ||||
| Age | |||||
| <60 | 18.4 | 0.043 | 1 | ||
| ≥60 | 27.5 | 0.42 | 0.22–0.83 | 0.012 | |
| Differentiation | |||||
| Good | 29.9 | 0.232 | |||
| Moderate+poor | 19.4 | ||||
| Lymph node invasion | |||||
| No (N0) | 30.2 | 0.449 | |||
| Yes (N1/2) | 20.2 | ||||
| Number of CRCLM | |||||
| <3 | 29.7 | 0.026 | 1 | ||
| ≥3 | 21.8 | 3.10 | 0.53–18.23 | 0.212 | |
| CRCLM distribution | |||||
| Unilobar | 26.1 | 0.695 | |||
| Bilobar | 27.8 | ||||
| HMGA1 | |||||
| Low | 34 | 0.014 | 1 | ||
| High | 17.7 | 2.37 | 1.26–4.44 | 0.007 | |
| GLUT3 | |||||
| Low | 29.5 | 0.039 | 1 | ||
| High | 22.6 | 0.58 | 0.10–3.46 | 0.554 | |
| * Log-rank test; ** Cox-regression model. | |||||