10 September 2020: Clinical Research
Prognostic Significance of CA125 Dynamic Change for Progression Free Survival in Patients with Epithelial Ovarian Carcinoma
Zemin Li BCEF , Han Yin CD , Mulan Ren AG , Yang Shen ACG*DOI: 10.12659/MSM.925051
Med Sci Monit 2020; 26:e925051
Table 1 Clinicopathological characteristics and Univariate analyses of the factors for progression-free survival.
| Clinicopathological characteristics | Cases | Mean PFS (95% CI) | χ2 | P |
|---|---|---|---|---|
| Age (y) | 0.947 | 0.331 | ||
| 54 | 21.44 (17.79~25.08) | |||
| ≥55 | 63 | 19.62 (16.37~22.87) | ||
| Histopathology | 1.101 | 0.294 | ||
| Serous carcinoma | 86 | 21.33 (18.41~24.25) | ||
| Others | 31 | 18.58 (14.02~23.15) | ||
| Differentiation | 8.643 | 0.003 | ||
| Well | 67 | 23.79 (12.93~19.71) | ||
| Poor, others | 50 | 16.32 (12.93~19.71) | ||
| Ascites | 0.475 | 0.491 | ||
| Yes | 60 | 19.76 (16.44~23.10) | ||
| No | 57 | 21.48 (17.81~25.13) | ||
| Vessel carcinoma embolus | 10.930 | 0.001 | ||
| Yes | 59 | 16.62 (13.59~19.66) | ||
| No | 58 | 24.65 (21.02~28.28) | ||
| FIGO stage | 9.782 | 0.002 | ||
| I–II | 45 | 25.74 (21.55~29.93) | ||
| III–IV | 72 | 17.39 (14.59~20.19) | ||
| Preoperative serum CA125 (U/mL) | 1.113 | 0.291 | ||
| ≤500 | 69 | 21.88 (18.70~25.06) | ||
| >500 | 48 | 18.76 (14.89~22.64) | ||
| Postoperative CA125 decline | 3.741 | 0.154 | ||
| 0.0~49.9% | 6 | 15.88 (15.57~16.20) | ||
| 50.0~75.0% | 48 | 18.64 (14.77~22.51) | ||
| >75.0% | 63 | 22.55 (19.10~25.99) | ||
| CA125 half-life (d) | 8.302 | 0.004 | ||
| ≤20 | 63 | 23.95 (20.56~27.35) | ||
| >20 | 54 | 16.68 (13.38~19.99) | ||
| CA125 negative time (w) | 8.506 | 0.004 | ||
| ≤8 | 60 | 24.15 (20.58~27.72) | ||
| >8 | 57 | 16.87 (13.74~19.99) | ||
| Preoperative NLR | 21.445 | 0.000 | ||
| ≤2.96 | 66 | 25.43 (22.18~28.69) | ||
| >2.96 | 51 | 14.34 (11.33~17.37) | ||
| Postoperative NLR change | 1.282 | 0.257 | ||
| Increase | 54 | 19.16 (15.70~22.61) | ||
| Decrease | 63 | 21.84 (18.36~25.32) | ||
| Preoperative PLR | 2.674 | 0.102 | ||
| ≤221 | 35 | 17.17 (12.59~21.75) | ||
| >221 | 82 | 22.07 (19.18~24.95) | ||
| Postoperative PLR change | 0.890 | 0.345 | ||
| Increase | 61 | 18.82 (15.49~22.16) | ||
| Decrease | 56 | 22.53 (18.93~26.14) |