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18 August 2020 : Clinical Research  

Effects of a Secondary Prevention Combination Therapy with beta-Blocker and Statin on Major Adverse Cardiovascular Events in Acute Coronary Syndrome Patients

Ling Zhu12ABCDEFG, Qianwei Cui1BCEF, Ying Liu3BCEF, Zhongwei Liu1BCE, Yong Zhang1BCF, Fuqiang Liu1ACDEFG, Junkui Wang1ACDEFG*

DOI: 10.12659/MSM.925114

Med Sci Monit 2020; 26:e925114

Supplementary Table 4 Multivariate COX analysis of progress to NYHA III or IV according to risk category of always b-blocker and statin treatment.

Progress to NYHA III or IVNo therapybeta-Blocker mono-therapyStatin mono-therapyCo-therapy
n=139n=71n=149n=277
Model 1a
 HR (95% CI)* 1.001.36 (0.43–4.30)0.26 (0.06–1.27)0.21 (0.05–0.80)
  value* 0.5980.0970.023
Model 2b
 HR (95% CI)* 1.001.18 (0.37–3.77)0.25 (0.05–1.21)0.20 (0.05–0.76)
  value* 0.7850.0850.018
Model 3c
 HR (95% CI)* 1.001.05 (0.32–3.38)0.24 (0.05–1.18)0.17 (0.04–0.65)
  value* 0.9420.0800.010
Model 4d
 HR (95% CI)* 1.001.04 (0.32–3.38)0.24 (0.05–1.23)0.17 (0.04–0.68)
  value* 0.9520.0880.013
* Compared with the no therapy group;
a Model 1: Unadjusted;
b Model 2: Multivariate adjustment was made for age, sex, smoking, body mass index;
c Model 3: Multivariate adjustment was made for age, sex, smoking, body mass index, diabetes, hypertension, old myocardial infarction, atrial fibrillation;
d Model 4: Multivariate adjustment was made for age, sex, smoking, body mass index, diabetes, hypertension, old myocardial infarction, atrial fibrillation, always use of aspirin, use of clopidogrel at 1 year, always use of ACEI or ARB, revascularization at baseline.
There were 0 cardiovascular death, 8 myocardial infarction, and 14 stroke during the follow-up. The incidence of cardiovascular death, myocardial infarction, and stroke were low and did not allow for further analysis. CI – confidence interval; HR – hazard ratio.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750