23 August 2020 : Database Analysis
Integrated Bioinformatics Analysis Reveals Potential Pathway Biomarkers and Their Interactions for Clubfoot
Jing Ding1BCDEF, Zhenpeng Liang1BCDE, Weijia Feng1EF, Qixun Cai1AG*, Ziming Zhang1AGDOI: 10.12659/MSM.925249
Med Sci Monit 2020; 26:e925249
Supplementary Table 1 Top 15 significantly changed pathways enriched by REAC database.
| Pathway identifier | Pathway name | Entities | Entities ratio | Interactors | Reactions | Reactions ratio | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| NO. | RANK | Ratio | RANK* | NO. | RANK* | NO. | RANK* | Ratio | RANK* | ||
| R-HSA-162582 | Signal transduction | 13 | 1 | 22.62% | 1 | 22 | 1 | 170 | 1 | 18.27% | 1 |
| R-HSA-73857 | RNA polymerase II transcription | 9 | 2 | 12.87% | 3 | 18 | 3 | 75 | 3 | 8.11% | 3 |
| R-HSA-212436 | Generic transcription pathway | 9 | 3 | 11.76% | 4 | 18 | 4 | 71 | 4 | 7.20% | 4 |
| R-HSA-74160 | Gene expression (transcription) | 9 | 4 | 10.77% | 5 | 21 | 2 | 71 | 5 | 6.69% | 5 |
| R-HSA-168256 | Immune system | 9 | 5 | 0.28% | 13 | 9 | 8 | 4 | 13 | 0.03% | 15 |
| R-HSA-109581 | Apoptosis | 7 | 6 | 18.81% | 2 | 12 | 5 | 70 | 6 | 12.60% | 2 |
| R-HSA-109606 | Intrinsic pathway for apoptosis | 7 | 7 | 0.59% | 9 | 9 | 9 | 14 | 9 | 0.56% | 9 |
| R-HSA-5357801 | Programmed cell death | 7 | 8 | 0.42% | 12 | 12 | 6 | 49 | 7 | 0.50% | 10 |
| R-HSA-3700989 | Transcriptional regulation by TP53 | 6 | 9 | 1.32% | 8 | 11 | 7 | 101 | 2 | 1.15% | 6 |
| R-HSA-168249 | Innate immune system | 6 | 10 | 2.24% | 6 | 8 | 10 | 12 | 10 | 1.08% | 7 |
| R-HSA-5633008 | TP53 regulates transcription of cell death genes | 6 | 11 | 1.80% | 7 | 8 | 11 | 12 | 11 | 0.91% | 8 |
| R-HSA-390522 | Striated muscle contraction | 6 | 12 | 0.49% | 10 | 0 | 15 | 29 | 8 | 0.44% | 11 |
| R-HSA-8939211 | ESR-mediated signaling | 6 | 13 | 0.48% | 11 | 4 | 12 | 2 | 14 | 0.30% | 12 |
| R-HSA-9006931 | Signaling by nuclear receptors | 6 | 14 | 0.23% | 14 | 4 | 13 | 6 | 12 | 0.21% | 13 |
| R-HSA-397014 | Muscle contraction | 6 | 15 | 0.14% | 15 | 1 | 14 | 1 | 15 | 0.07% | 14 |
| * Ranked in the top 15 entities found, not in total significantly changed pathways. | |||||||||||