23 August 2020 : Database Analysis
Integrated Bioinformatics Analysis Reveals Potential Pathway Biomarkers and Their Interactions for Clubfoot
Jing Ding1BCDEF, Zhenpeng Liang1BCDE, Weijia Feng1EF, Qixun Cai1AG*, Ziming Zhang1AGDOI: 10.12659/MSM.925249
Med Sci Monit 2020; 26:e925249
Supplementary Table 2 Top functions enriched.
| Database | Name | NetworkAnalyst | WebGestalt | g: Profiler | Average |
|---|---|---|---|---|---|
| REAC | Apoptosis/PCD | 81.8 | 86.4 | 84.2 | 84.1 |
| Muscle contraction | 9.1 | 9.1 | 10.5 | 9.6 | |
| Metabolism | 4.5 | 0.0 | 5.3 | 3.3 | |
| Immune system | 4.5 | 4.5 | 0.0 | 3.0 | |
| KEGG | Disease | 64.3 | 75.0 | 75.0 | 71.4 |
| Apoptosis/PCD | 7.1 | 10.0 | 12.5 | 9.9 | |
| Cell cycle | 7.1 | 5.0 | 6.3 | 6.1 | |
| Metabolism | 7.1 | 5.0 | 6.3 | 6.1 | |
| Cell-cell communication | 7.1 | 5.0 | 0.0 | 4.1 | |
| Muscle contraction | 7.1 | 0.0 | 0.0 | 2.4 | |
| WP | Disease | ND | ND | 36.8 | 36.8 |
| Apoptosis/PCD | ND | ND | 26.3 | 26.3 | |
| DNA damage/repair | ND | ND | 15.8 | 15.7 | |
| Muscle contraction | ND | ND | 5.3 | 5.3 | |
| Immune system | ND | ND | 5.3 | 5.3 | |
| Cell response | ND | ND | 5.3 | 5.3 | |
| Signal Transduction | ND | ND | 5.3 | 5.3 | |
| Mixed | Apoptosis/PCD | 84.1 | 9.9 | 26.3 | 40.1 |
| Disease | 0.0 | 71.4 | 36.8 | 36.1 | |
| Muscle contraction | 9.6 | 2.4 | 5.3 | 5.8 | |
| DNA damage/repair | 0.0 | 0.0 | 15.7 | 5.2 | |
| Metabolism | 3.3 | 6.1 | 0.0 | 3.1 | |
| Immune system | 3.0 | 0.0 | 5.3 | 2.8 | |
| Cell cycle | 0.0 | 6.1 | 0.0 | 2.0 | |
| Cell response | 0.0 | 0.0 | 5.3 | 1.8 | |
| Signal Transduction | 0.0 | 0.0 | 5.3 | 1.8 | |
| Cell-cell communication | 0.0 | 4.1 | 0.0 | 1.4 |