20 September 2020: Clinical Research
Correlation Between Plasma Matrix Metalloproteinase-28 Levels and Severity of Calcific Aortic Valve Stenosis
Ke Zhou 1BCE* , Ting Guo 2EF* , Yawei Xu 1CDG , Rong Guo 1ADG*DOI: 10.12659/MSM.925260
Med Sci Monit 2020; 26:e925260
Table 2 Echocardiographic parameters.
| Variables | AVA (cm2) | Mean gradient (mmHg) | SVi (mL/m2) | Total | |||||
|---|---|---|---|---|---|---|---|---|---|
| >1.5 | 1.0–1.5 | <1.0 | <20 | 20–40 | >40 | ≤35 | >35 | ||
| n | 25 | 33 | 21 | 24 | 31 | 24 | 47 | 32 | 79 |
| LVEDD (mm), mean±SD | 48.0±4.6 | 49.1±4.9 | 48.8±4.9 | 46.7±4.2 | 50.3±5.1 | 48.6±4.5 | 49.3±4.9 | 47.8±4.7 | 48.7±4.8 |
| IVST (mm), mean±SD | 13.2±1.8 | 12.8±2.1 | 13.1±1.9 | 13.3±1.8 | 12.7±2.2 | 13.1±1.8 | 13.4±1.9 | 12.5±1.9 | 13.0±1.9 |
| LVPWT (mm), mean±SD | 13.6±2.1 | 12.6±1.9 | 13.1±2.1 | 13.5±2.0 | 12.8±2.0 | 13.0±1.9 | 13.3±1.9 | 12.6±2.0 | 13.1±2.0 |
| Peak transaortic valve flow velocity (m/s), mean±SD | 2.9±0.3 | 3.4±0.4 | 5.3±1.1 | 2.8±0.1 | 3.4±0.3 | 5.2±1.1 | 3.7±1.1 | 3.9±1.3 | 3.8±1.2 |
| Mean transaortic pressure gradient (mmHg), mean±SD | 25.3±2.0 | 31.4±2.9 | 50.1±10.0 | 34.3±1.3 | 34.3±1.3 | 34.3±1.3 | 33.6±10.4 | 35.6±12.6 | 34.3±1.3 |
| LVEF (%), mean±SD | 51.9±10.0 | 52.6±13.2 | 53.5±11.1 | 53.8±10.6 | 53.7±12.4 | 50.0±11.7 | 50.6±10.0 | 54.2±12.5 | 52.6±11.6 |
| Associated aortic regurgitation >II/IV, n (%) | 10 (12.7) | 18 (22.8) | 16 (20.2) | 11 (13.9) | 16 (20.2) | 17 (21.5) | 24 (30.4) | 20 (25.3) | 44 (55.7) |
| AVA (cm), mean±SD | 1.9±0.2 | 1.4±0.3 | 0.8±0.2 | 1.9±0.2 | 1.4±0.3 | 0.8±0.2 | 1.4±0.4 | 1.3±0.5 | 1.4±0.5 |
| SVi (mL/m), mean±SD | 34.6±7.7 | 32.9±6.7 | 28.9±8.2 | 34.7±7.5 | 32.8±6.9 | 29.3±8.1 | 28.6±4.2 | 37.9±8.2 | 32.4±7.7 |
| LVEDD – left ventricular end-diastolic dimension; IVST – interventricular septal thickness; LVPWT – left ventricular posterior wall thickness; LVEF – left ventricular ejection fraction; AVA – aortic valve area; SVi – stroke volume index; SD – standard deviation. | |||||||||