27 September 2020: Clinical Research
Association Between Serum Uric Acid and Depression in Patients with Chronic Kidney Disease not Requiring Kidney Dialysis: Cross-Sectional and Longitudinal Analyses
Bin Gao 1B , Xinyuan Song 1D , Jie Hao 1F , Yingying Han 1C , Miaomiao Zhang 1B , Na Sun 1E , Jinping Li 1F , Pingping Qi 1F , Shunya Uchida 2E , Wenxiu Chang 1AG*DOI: 10.12659/MSM.925386
Med Sci Monit 2020; 26:e925386
Table 4 Longitudinal changes in clinical parameters in patients with and without BDI decline (n=158).
| Characteristic | With BDI decline (n=72) | Without BDI decline (n=86) | P value* |
|---|---|---|---|
| BDI score change | −3.00 [−5.00, −1.00] | 1.00 [0.00, 2.00] | |
| PSQI score change | −1.44±3.62 | 0.02±2.82 | 0.005 |
| eGFR change, mL/min/1.73 m | 0.15±1.05 | −1.39±7.51 | 0.272 |
| SBP change, mmHg | −0.74±14.97 | −1.55±14.20 | 0.744 |
| BMI change, kg/m | −0.32±1.33 | −0.06±0.93 | 0.175 |
| Blood parameters | |||
| Hb change, g/dL | −2.54±12.52 | 0.90±1.89 | 0.093 |
| Na change, mEq/L | 1.22±2.69 | 0.48±2.88 | 0.135 |
| K change, mEq/L | −0.005±0.682 | −0.061±0.604 | 0.622 |
| Cl change, mEq/L | 0.93±3.37 | −1.12±12.32 | 0.204 |
| Ca change, mmol/L | −0.02±0.18 | −0.01±0.14 | 0.752 |
| P change, mmol/L | 0.09±0.24 | 0.06±0.21 | 0.469 |
| Mg change, mmol/L | 0.02±0.10 | −0.03±0.09 | 0.114 |
| BUN change, mmol/L | 0.41±4.37 | 3.37±2.63 | 0.302 |
| Cr change, mg/dL | 2.03±1.85 | 2.00±1.53 | 0.902 |
| UA change, mg/dL | 0.45±1.69 | −0.53±1.96 | 0.002 |
| Alb change, g/dL | 3.91±0.44 | 3.80±0.59 | 0.223 |
| TC change, mmol/L | −0.35±0.89 | −0.32±1.31 | 0.910 |
| TG change, mmol/L | −0.05±0.83 | −0.32±0.95 | 0.337 |
| CO change, mEq/L | −0.20±2.39 | 0.31±3.18 | 0.407 |
| UB score of spot urine change | 0.00 [−1.00, 0.00] | 0.00 [0.00, 0.00] | 0.341 |
| 24-hour urine protein change, g/day | 0.00 [−1.00, 1.00] | 0.00 [−1.00, 0.00] | 0.272 |
| * Independent Sample T test or Mann-Whitney U test (BDI score change, UB score of spot urine change and 24-hour urine protein change) as appropriate. Alb – albumin; BDI – Beck Depression Inventory; BMI – body mass index; BUN – blood urea nitrogen; Ca – calcium; Cl – chlorine; CO – venous carbon dioxide; Cr – creatinine; eGFR – estimated glomerular filtration rate; Hb – hemoglobin; K – potassium; Mg – magnesium; Na – sodium; P – phosphorus; PSQI – Pittsburgh Sleep Quality Index; SBP – systolic blood pressure; TC – total cholesterol; TG – triglyceride; UA – uric acid; UB – urine blood. | |||