18 September 2020: Database Analysis
Development and Validation of a Novel Immune-Gene Pairs Prognostic Model Associated with CTNNB1 Alteration in Hepatocellular Carcinoma
Junyu Huo ABCDEF , Liqun Wu AEF* , Yunjin Zang AEDOI: 10.12659/MSM.925494
Med Sci Monit 2020; 26:e925494
Table 2 The chi-square test of the relation between risk score and clinical features in TCGA.
| Clinical feature | Risk score | χ2 | P | |
|---|---|---|---|---|
| High risk n(%) | Low risk n(%) | |||
| AFP | 1.482 | 0.223 | ||
| >300 ng/ml | 22 (35.48%) | 40 (64.52%) | ||
| ≤300 ng/ml | 54 (27.41%) | 143 (72.59%) | ||
| Age | 0.079 | 0.779 | ||
| >65 | 46 (36.22%) | 81 (63.78%) | ||
| ≤65 | 75 (34.72%) | 141 (65.28%) | ||
| BMI | 4.461 | 0.035 | ||
| >25 | 42 (27.45%) | 111 (72.55%) | ||
| ≤25 | 63 (38.65%) | 100 (61.35%) | ||
| Family cancer history | 0.149 | 0.699 | ||
| No | 29 (23.58%) | 94 (76.42%) | ||
| Yes | 19 (26.03%) | 54 (73.97%) | ||
| Gender | 0.282 | 0.595 | ||
| Female | 54 (42.90%) | 69 (56.10%) | ||
| Male | 80 (34.33%) | 153 (65.67%) | ||
| Tumor status | 14.215 | 0.001 | ||
| Tumor free | 45 (25.14%) | 134 (74.86%) | ||
| With tumor | 67 (44.97%) | 82 (55.03%) | ||
| New tumor event after initiate treatment | 9.012 | 0.003 | ||
| No | 43 (26.54%) | 119 (73.46%) | ||
| Yes | 71 (42.26%) | 97 (57.74%) | ||
| Prior malignancy | 2.406 | 0.121 | ||
| No | 114 (36.53%) | 198 (63.46%) | ||
| Yes | 7 (22.58%) | 24 (77.42%) | ||
| Histologic grade | 9.308 | 0.025 | ||
| G1 | 10 (18.87%) | 43 (81.13%) | ||
| G2 | 56 (34.78%) | 105 (65.22%) | ||
| G3 | 48 (42.86%) | 64 (57.14%) | ||
| G4 | 5 (41.67%) | 7 (58.33%) | ||
| AJCC stage | 26.373 | 0.001 | ||
| I | 37 (22.98%) | 124 (77.02%) | ||
| II | 29 (37.66%) | 48 (62.34%) | ||
| III–IV | 45 (56.25%) | 35 (43.75%) | ||
| Vascular tumor cell type | 10.5 | 0.005 | ||
| None | 50 (26.60%) | 138 (73.40%) | ||
| Micro | 29 (34.12%) | 56 (65.88%) | ||
| Macro | 10 (62.50%) | 6 (37.50%) | ||
| Race | 3.835 | 0.147 | ||
| White | 55 (32.54%) | 114 (67.46%) | ||
| Asian | 59 (39.86%) | 89 (60.14%) | ||
| Blank & Indian | 3 (18.75%) | 13 (81.25%) | ||