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20 September 2020: Meta-Analysis

Efficacy and Toxicity of Adjuvant Therapies for High-Risk Endometrial Cancer in Stage I–III: A Systematic Review and Network Meta-Analysis

Mengyin Ao 12ABCDEF , Ting Ding 12BF , Dan Tang 12E , Mingrong Xi 12E*

DOI: 10.12659/MSM.925595

Med Sci Monit 2020; 26:e925595

Table 1 Characteristics of included randomized clinical trials.

AuthorSub-categoryLocationFIGO stageInterventionSample sizeAge, years median (range)
Randall et al.GOG-249USAI–IIAB30130060163 (NR)65 (NR)
Hogberg et al. (1)NSGO-RORTCSwedenI–IIICAC19118737864 (44–79)64 (38–83)
Hogberg et al. (2)MangoSwedenII–IIIAC768015659 (42–78)58 (39–77)
Morrow et al.GOG-34USAI–II occultAC8992181NRNR
Kuoppala et al.NRFinlandI–IIIAAC728415674 (47–86)73 (47–85)
de Boer et al.PORTEC-3France, Italy, CanadaI–IIIAC33033066062 (NR)62 (NR)
Creutzberg et al.PORTEC-1NetherlandsI–IIICAD35436071466 (41–85)66 (43–90)
Keys et al.GOG-99USAI–II occultAD19020239263 (NR)63 (NR)
Blake et al.ASTEC/EN5UK, Canada, PolandI–IIBAD45245390565 (36–88)66 (31–88)
Susumu et al.JGOGJapanIC–IIICAE193192385NRNR
Maggi et al.NRItalyIC–IIICAE16617434062 (NR)63 (NR)
Sorbe et al.NRSwedenIA–ICFG264263527NRNR
Sunil et al.NRIndiaIA–IBFG252550NRNR
Nout et al.PORTEC-2DutchIB–IIAAG21421342769 (NR)70 (NR)
A – pelvic radiotherapy; B – vaginal cuff brachytherapy and chemotherapy; C – pelvic radiotherapy and chemotherapy; D – No further treatment; E – chemotherapy; F – pelvic radiotherapy and vaginal brachytherapy; G – vaginal brachytherapy.
a Based on FIGO 2009 classification;
b based on FIGO 1988 classification;
c based on FIGO 2009 classification;
NR – not reported.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750