25 June 2020 : Meta-Analysis
The Analysis for Anemia Increasing Fracture Risk
Yirong Teng1ABCDEF, Zhaowei Teng1ABCDEFG, Shuanglan Xu2BCE, Xiguang Zhang1CEF, Jie Liu2BCE, Qiaoning Yue1BCE, Yun Zhu1AFG*, Yong Zeng1ABFDOI: 10.12659/MSM.925707
Med Sci Monit 2020; 26:e925707
Table 2 Characteristics of 6 studies included in the final analysis of anemia and fracture risk.
| Author, year (location) | Age | Fracture type/assessment | Study design | Study size | Follow-up time | Models | Adjustment for covariates | NOS |
|---|---|---|---|---|---|---|---|---|
| Chen, 2010 (United States) | 63.2±7.2 y | Hip/medical records spine/Self-reported any/Self-reported | P, C | 8739 | 7.8 y | Cox proportional hazards models | Arm assignment, interventions, race/ethnicity, age, height, weight, self-reported general health, baseline number of falls, diabetes | 9 |
| Jorgensen, 2010 (Norway) | 55 to 74 y | Nonspine/radiographic archives of the University Hospital of North Norway | P | 5286 | 8.3 y | Cox regression analyses | Age, height, BMI, serum total cholesterol, HDL-cholesterol, serum triglycerides, serum creatinine, smoking, use of alcohol, grip strength, and distal forearm BMD | 9 |
| Zapatero, 2013 (Spain) | 71.3±16.8 y | Hip/ICD-9 codes | RO | 1991911 | NA | logistic regression analysis | – | 7 |
| Looke, 2014 (United States) | ≥65 y | Hip/ICD-9 codes | RO | 2122 | NA | Cox proportional hazards models | Age, sex, ever smoked, femur neck BMD, iron/folate deficiency, inflammation, renal insufficiency, BMI, timed chair stand | 7 |
| Valderrabano, 2017 (United States) | ≥65 y | Any/Self-report nonspine/Self-report spine/Self-report | P, C | 3632 | 7.2 y | Cox proportional hazards models | – | 9 |
| Lee, 2019(South Korea) | ≥65 y | Any/ICD-10 codes spine/ICD-10 codes hip/ICD-10 codes | R, C | 72131 | 8.0 y | Cox proportional hazards models | Age, sex, BMI, alcohol, smoking history, and physical activity | 8 |
| Shin, 2019(Korea) | 58.4±11.8 y | Any/Self-report | R, C | 133179 | 4.5 y | Cox proportional hazards models | Age, sex, residence, income, and disability | 9 |
| y – years; P – prospective; R – retrospective; C – cohort; RO – retrospective observational; BMI – body mass index; BMD – bone mineral density; HDL – high density lipoprotein; NOS – Newcastle-Ottawa Scale. | ||||||||